摘要
目的探讨老年人主动脉瓣钙化的发生率、瓣膜功能及与老年人常见疾病的相关性。方法对在我院查体的966例患者进行超声心动图检查，根据年龄分为老年组733例和非老年组233例，老年组根据有无主动脉瓣钙化分为钙化组526例和非钙化组207例，测量主动脉瓣有无钙化、狭窄或关闭不全，用Logistic回归分析钙化发生的危险因素。结果（1）老年组主动脉瓣钙化发生率高于非老年组71．8％（526例）与14．6％（34例），差异有统计学意义（x2=237．10，P〈0．01）；（2）钙化组、非钙化组合并主动脉瓣狭窄的发生率分别为2．1％（11／526）、1．9％（4／207），差异无统计学意义（z。一0．81，P〉O．05）；（3）老年性主动脉瓣钙化组、非钙化组合并主动脉瓣关闭不全的发生率分别为63．3％（333／526）、19．3％（40／207），差异有统计学意义（x2=116．10，P〈O．01）；（4）不同疾病发生主动脉瓣钙化的相对风险（OR）分别为：高血压（OR=2．06，95％CI：1．4003．031）、冠心病（OR=3．46，95％CI：2．217～5．384），糖尿病（OR=2．66，95％CI：1．652～4．278）、慢性肾脏病（OR=2．34，95％CJ：1.415～3．869，P〈0．01），骨质疏松（OR=2．33，95％CI：1．119～4．838）。结论老年患者主动脉瓣钙化发生率较高，多为主动脉瓣关闭不全，高血压、冠心病、糖尿病、慢性肾脏疾病、骨质疏松患者更易发生主动脉瓣钙化。
Objective To evaluate the incidence of aortic valve calcification, and the correlation between valve function and commonly encountered disease in the aged patients. Methods Totally 996 patients who underwent ultrasonic cardiography （UCG） in our hospital were included. They were divide into elderly group and non elderly group, and the elderly group was divided into calcification subgroup and non calcification subgroup. The calcification, stenosis and regurgitation of aortic valve were detected by UCG, and risk factors of calcification were evaluated by Logistic regression analysis. Results The incidence of calcification was higher in elderly group than in non elderly group [71.8% （526/733） vs. 14.6% （34/233）, Z2=237.10,P^0.01]. In elderly group, the incidence of aortic valve stenosis was 2.1% （11/526） in calcification subgroup and 1.9% （4/207） in non calcification subgroup （2= 0.81, P~ 0.05）. In elderly group, the incidence of aortic valve regurgitation was 63.3% （333/526） in calcification subgroup and 19.3% （40/207） in non calcification subgroup （X~： 116.10,P^0.01）. The hazard ratio of aortic valve calcification in different diseases were as follows.. hypertension （OR=2.06, 95%CI：1. 400-3. 031）, coronary heart disease （OR=3.46, 95%CI：2. 217- 5. 384）, diabetes mellitus （OR = 2.66, 95 % CI： 1. 652-4. 278）, renal dysfunction （OR = 2.34, 95 % CI：I. 415-3. 869）, osteoporosis （OR= 2.33, 95%CI~ 1. 119-4. 838）. Conclusions The incidence of calcification, mainly causing aortic valve regurgitation, is high in elderly patients. Patients with hypertension, coronary heart disease, diabetes mellitus, renal dysfunction and osteoporosis are prone to the development of aortic valve calcification.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第12期1051-1053,共3页
Chinese Journal of Geriatrics
基金
国家自然科学基金资助项目（40972210）
关键词
主动脉瓣
动脉硬化
Aortic valve
Arteriosclerosis
