摘要
目的 :研究预注法和增大剂量法对罗库溴铵起效时间的影响。方法 :5 0例病人分为五组 ,每组 10例。Ⅰ组、Ⅱ组分别单次静注罗库溴铵 0 6mg/kg、0 75mg/kg。Ⅲ组、Ⅳ组为预注组 ,初始总剂量均为 0 6mg/kg,预注量分别为0 0 6mg/kg、0 12mg/kg。预注间隔 2分钟后 ,静注插管量 ,Ⅲ组 0 5 4mg/kg、Ⅳ组 0 48mg/kg。Ⅴ组为单次静注琥珀胆碱1 5mg/kg。观察各组肌松的起效时间、气管插管条件及心血管反应。结果 :Ⅰ～Ⅴ组肌松起效时间分别为 10 6 3± 46 8、98 6± 19 9、99 1± 2 7 5、95 7± 2 8 0、94 7± 2 5 3秒。组间比较无显著差异。气管插管条件及心血管反应亦无显著差异。结论 :2～ 2 5ED95罗库溴铵起效时间与琥珀胆碱接近。
Objective:To study the effect of high dose or priming injection on the onset time of rocuronium.Methods:Fifty patients were randomly divided into five groups with 10 each.After induction of anesthesia,a bolus of 0 6mg/kg rocuronium was given iv in group 1 and 0 75mg/kg in group 2.A priming dose of 0 06mg/kg、0.12mg/kg rocuronium was injected at 2min prior to 0 54mg/kg、0 48mg/kg intubating dose in group3、in group4.In group 5 succinylcholine 1 5mg/kg was given in bolus.The onset time,intubation conditions and circulatory effects of rocuronium were recorded.Results:The onset times of rocuronium of five groups were 106 3±46 5,98 6±19 9,99 1±27 5,95 7±28 0 and 94 7±25 3 s respectively.There was no any significant difference in intubatton condition and cardiovascular side effict.Conclutions:The onset time of 2～2 5ED 95 rocuronium is similar to that of 1 5mg/kg succinylcholine,suggesting that “priming” does not shorten the onset time of rocuronium.
出处
《临床麻醉学杂志》
CAS
CSCD
2000年第5期228-229,共2页
Journal of Clinical Anesthesiology
