摘要
目的 进一步探讨母婴之间巨细胞病毒 (CMV)的感染与传播。方法 对 36对母婴配对的尿和 16例母乳标本进行CMV分离 ,其中 2 6例检测CMVIgM抗体。 结果 婴儿尿CMV分离阳性率为 47 2 % ,其中 1个月内、～ 4个月、～ 1岁婴儿阳性率分别为 0、6 0 0 %和 33 3 % ,存在显著差异 (χ2 =6 5 7,P <0 0 5 )。母亲母乳CMV分离阳性率为 75 % ,显著高于其尿的排毒率 5 6 % (χ2 =2 3 74,P <0 0 1)。在喂养方式中 ,纯母乳喂养儿CMV阳性率为 5 7 7%与非纯母乳喂养儿的 2 0 %相比 ,差异显著 (χ2 =4 12 ,P <0 0 5 )。在不同病种中 ,婴儿肝炎综合征(婴肝 )患儿CMV培养及IgM的阳性率为 5 5 % ,支气管肺炎患儿CMV阳性率则高达 80 % ,而 6例其它病种患儿仅 2例阳性。结论 母乳是婴儿获得CMV感染的主要来源。
Objective To investigate the cytomegalovirus(CMV)infection and transmission between mothers and infants.Methods Thirty-six mother-infant pairs'urine and sixteen mothers'breast milk were examined for cytomegalovirus isolation and sera of twenty-six infants for anti-CMV IgM antibody were detected.Results The positive rate of cytomegalovirus isolation in urine of infant was 47 2%,in which,age of <1 month,1～3 months and 4 months to 1 year were zero,60 0% and 33 3%,respectively(χ 2=6 57,P<0 05).CMV culture positive rate in breast milk(75%) was markedly higher than that in urine (5 6%)(χ 2=23 74,P<0 01).In different styles of feeding,there was significant difference of CMV positive rate from infants on breast feeding (57 7%)to those on mixed feeding(20%)(χ 2=4 12,P<0 05).In different diseases,the positive rates of CMV isolation and anti-CMV IgM antibody were 55% in infantile hepatitis syndrome and isolation of CMV was 80% in pneumonitis and only 2 cases were positive in 6 other diseases.Conclusion Breast milk is the major source of CMV infection acquired by infant.Infantile hepatitis syndrome and pneumonitis of the younger are mainly infected by CMV.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第6期355-356,共2页
Chinese Journal of Practical Pediatrics
关键词
巨细胞病毒感染
母婴传播
CMV
抗体
Cytomegalovirus Infection Transmission in mother and infant
