摘要
目的 根据肝门部胆管癌的病理学特点 ,在行根治性手术时可能需采用肝十二指肠韧带的整块切除。本研究就是要了解用门静脉动脉化重建肝血流的可行性。方法 建立门静脉动脉化重建肝脏血流的梗阻性黄疸大鼠实验模型 ,通过该模型对大鼠的一般情况及对肝细胞凋亡的影响进行观察。结果 行门静脉动脉化手术后 1周黄疸完全消退 ,术后 7～ 10d体重即可恢复术前水平 (5 / 5 )。流式细胞仪和DNA电泳检测显示无 1例出现肝细胞凋亡 (0 / 5 )。结论 该方法在临床上具有一定的可行性和有应用的前景。
Objective This study was to evaluate the feasibility of hepatopetal blood flow reconstruction by the arterialization of portal vein after an en bloc resection of the hepatoduodenal ligament in a rat model with experimental obstructive jaundice.Methods Experimental model was established in rats by common bile duct ligation.Operative effect of portal venous arterialization on the general conditions of rats was viewed and apoptosis of liver cell investigated. Results Jaundice disappeared completely within one week after arterialization of portal vein,weights could be restored (5/5) within 7～10 days.Apoptosis of liver cell was not induced (0/5).Conclusions The method of hepatic blood flow reconstruction after resection of the hepatoduodenal ligament may be applicable for clinical use.
出处
《中华普通外科杂志》
CSCD
2000年第6期348-351,共4页
Chinese Journal of General Surgery
