摘要
目的 提高肝门部胆管癌术后辅助化疗的治疗效果。方法 采用四甲基偶氮唑盐快速比色法对 2 5例手术切除的肝门部胆管癌新鲜标本作 8种临床常用化疗药物的敏感性测试。结果 该组织类型的肿瘤对抗癌药物的敏感性存在明显的个体差异。其中对表阿霉素的共同敏感率为 5 8% (14/2 4) ,阿霉素、卡铂均为 5 4% (13/2 4) ,顺铂为 5 0 % (12 /2 4) ,氟脲嘧啶为 17% (4/2 4) ,甲氨喋呤为 4% (1/2 4)。结论 应用化疗药物敏感性检测方法对肝门部胆管癌病人进行个体化选药 ,有利于提高术后的综合治疗效果。本组实验结果提示 ,在肝门部胆管癌的化疗中 ,蒽环类、铂化合物类抗肿瘤药可能是较为有效的。
Objective To improve the effect of postoperative chemotherapy for patients with hilar cholangiocarcinoma. Methods Using MTT assay we detected the individual sensitivity of primary culture of hilar cholangiocarcinoma to 5 FU, MMC, ADM, EPB, MTX, CTX, CDDP and Carboplatin in 24 patients. Results Tumors varied significantly in their sensitivity to the above mentioned chemotherapeutic agents and were characteristic of individual discrepancy as well.Tumors' sensitivity rate to EPB is 58% (14/24) and 54%(13/24) to both ADM and Carboplatin, 50%(12/24) to CDDP, 46%(11/24) to MMC, 17%(4/24) to 5 FU,4%(1/24) to MTX and 0/24 to CTX, respectively. Conclusion Our observation shows that the MTT assay is useful method for selecting effective chemotherapeutant for an individual patient undergoing resection of hilar cholangiocarcinoma.According to our result anthracycline antibiotic and platinum compound are more effective than others for the treatment of human hilar cholangiocarcinoma.
出处
《中华普通外科杂志》
CSCD
2000年第6期335-337,共3页
Chinese Journal of General Surgery
