摘要
目的 探讨高血压家族史 (HPHIS)阳性人群与糖尿病患病的关系。方法 对我国 19个省市 2 5岁以上的 2 5万人糖尿病普查中 15 2 2 4人按有无HPHIS分成阳性和阴性组 ,按 1997年美国ADA标准分为正常人 (NGT)、糖耐量低减 (IGT)、糖尿病 ,进行组间比较及多因素回归分析。结果(1)HPHIS阳性组与阴性组比较年龄、BMI、WHR、血糖、血压显著增高 (P <0 0 0 0 1) ,但两组糖尿病家族史 (DMHIS)差异无显著性。 (2 )总体人群分成正常人、IGT、糖尿病后HPHIS阳性率 (分别为13 86 % ,19 5 8% ,2 9 2 0 % )比较差异有显著性 (P <0 0 0 1)。 (3)对正常人和IGT或糖尿病人群进行多因素回归分析 ,HPHIS也与IGT或糖尿病的发生呈独立正相关。结论 (1)HPHIS阳性人群的BMI、WHR、血压、血糖水平均显著高于阴性组。 (2 )HPHIS阳性与糖尿病、IGT的发生呈独立正相关 。
Objective To explore the relationship between the subjects with family history of hypertension (HPHIS) and incidence of diabetes mellitus (DM). Methods Data were drawn from the national diabetes survey for 19 provinces and cities altogether 250 000 adults over 25 years old were studied. 15 224 diabetic patients were divided into two groups, positive HPHIS and negative HPHIS. According to the criteria of 1997 US ADA, the patients were also divided into normal glucose tolerance (NGT), impaired glucose tolerance (ING), and DM groups. The measurement methods for glucose, BMI, WHR, blood pressure are same as those in the study for IGT, DM in Daqing. The statistics were carried out by the comparison between groups with SAS soft ware and multiple logistic regression analysis. Results 1 The positive HPHIS group was higher in age, BMI, glucose, blood pressure than the negative HPHIS group ( P <0.000 1), but there was no significant difference in DM history between the two groups. 2 Among the NGT, IGT and DM groups, the percentage of positive HPHIS (13 86%, 19.58%, 29.20%,respectively).has significant difference ( P <0.001). 3. When multiple logistic, regression analysis for NGT and DM was taken and DM was made as the dependent variable, while age, sex, BMI, WHR, HPHIS and DM history were made as the independent variables, HPHIS was related with DM positively after above mentioned independent variables were adjusted. 4. The same result was obtained by taking multiple logistic, regression analysis for NGT and IGT. Conclusion 1. There are higher BMI, WHR, blood pressure and blood glucose in the positive HPHIS than in the negative HPHIS and there is obvious tendency of insulin resistance. 2. Positive HPHIS are positively associated with DM and IGT independently. It is suggested that the population with positive HPHIS may be an important risk factor for development of DM.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2000年第6期395-397,共3页
Chinese Journal of Internal Medicine
