摘要
目的 探讨原发性肝胆管结石与肝胆管癌的关系 ,总结本病的诊治经验。方法 对1981～ 1998年间收治的 2 0例原发性肝胆管结石术后并发肝胆管癌的病例进行回顾性临床分析。结果 本组病人均有 10～ 40年肝胆管结石病史 ,曾经过 1～ 5次胆道手术。主要临床表现是反复胆管炎发作和持续右上腹疼痛。由于本病早期诊断困难 ,大多数病人在手术时已属晚期 ,5年生存率仅5 % ,80 %病人在术后 1年内死亡。病理诊断大多为腺癌。结论 原发性肝胆管结石慢性炎症长期刺激和上皮增生可能是诱发胆管癌的原因 ,提高远期疗效的关键是早期发现、及时手术。
Objective To probe into the relationship between the hepatolithiasis and the intrahepatic cholangiocarcinoma, and to summarize the experiences of diagnosis and treatment of these diseases. Method A retrospective clinical analysis was made in 20 cases of hepatolithiasis complicated by intrahepatic cholangiocarcinoma between 1981 and 1998. Results All patients had suffered from hepatolithiasis for 10 to 40 years, and had been subjected to operations for biliary diseases. The clinical features were recurrent attack of cholangitis and persistent right epigastric pain. Because early diagnosis was very difficult, most patients were of late stages on operations. The 5 year survival rate in this series of patients was 5% and about 80% of them died within 1 year after operation. By pathological classification most of them were adenocarcinomas. Conclusions Long term chronic inflammatory stimulation due to primary hepatolith and epithelial hyperplastic lesions are the causes inducing intrahepatic cholangiocarcinoma and early diagnosis and resection on time might improve the therapeutic effecacy.
出处
《中华肝胆外科杂志》
CAS
CSCD
2000年第3期181-182,共2页
Chinese Journal of Hepatobiliary Surgery
