摘要
研究盐酸阿霉素缓释剂在大鼠和犬体内的药物动力学。方法 :用高效液相色谱法测定血浆阿霉素的浓度。结果 :大鼠皮下植入盐酸阿霉素缓释剂后 ,血浆阿霉素可持续、缓慢释放 ;犬皮下植入 2mg·kg-1盐酸阿霉素缓释剂后 ,其有效血浆浓度曲线呈一室模型特点 ,但其维持有效血浆浓度 (0 .0 4μg .ml-1)时间长达 16 8h ,其峰值浓度仅为iv同剂量血浆阿霉素的4.6 %。结论 :盐酸阿霉素缓释剂有显著的缓释作用。
OBJECTIVE:To study the pharmacokinetics of adriamycin sustained release pellet (ADMSRP) in rats and dogs.METHODS:The concentration of adriamycin (ADM) in plasma was measured by HPLC.RESULTS:ADM could be released slowly and lasted in plasma after subctaneous embedding of ADMSRP in rats; after intramuscular embedding (ime) of ADMSRP in dogs, the plasma durg concentration-time curve showed the characteristics of one compartment model,the peak concenatration of ime ADMSRP was only 4.6% of that of iv same dose ADM, but the time of effective plasma concentration ( 0.04μg·ml -1) was 168h.CONCLUSION:ADMSRP possesses significant sustained-release effect.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第6期323-324,共2页
Chinese Journal of Hospital Pharmacy
关键词
阿霉素
药物动力学
缓释剂
adriamycin
sustained-release preparation
pharmacokinetics
