摘要
目的:测定吴茱萸碱分散片及吴茱萸碱经不同方法处理后的溶出度。方法:依据《中华人民共和国药典》2010年版溶出度测定法第二法(浆法),以1%SDS 900 mL为溶出介质,转速100 r.min-1;制备吴茱萸碱-泊洛沙姆188固体分散体、吴茱萸碱超微粉及吴茱萸碱超微粉-泊洛沙姆188固体分散体,HPLC测定溶出度。结果:吴茱萸碱分散片45 min溶出度>60%;吴茱萸碱超微粉-泊洛沙姆188固体分散体体外溶出度较好。结论:建立的吴茱萸碱分散片溶出度测定方法简便、快速,可作为吴茱萸碱分散片的溶出度检测方法;吴茱萸碱几乎不溶于水,超微粉碎联合固体分散体技术能显著提高吴茱萸碱的溶出度。
Objective： To determine dissolution of evodiamine dispersible tablets and evodiamine which were processed by different methods. Method： According to the second dissolution method （slurry method） in 2010 edition Chinese Pharmacopoeia＇, 1% SDS solution Of 900 mL was used as dissolution medium, rotation speed was 100 r · min^-1, HPLC was as quantitative method to determine dissolution, evodiamine-poloxamer 188 solid dispersions, evodiamine ultrafine powder and evodiamine ultrafine powder-poloxamer 188 solid dispersions were prepared. Result： Ddissolution of evodiamine dispersible tablets was more than 60% at 45 rain; Dissolution of evodiamine ultrafine-poloxamer 188 solid dispersions was higher than others. Conclusion： This established dissolution determination method of evodiamine dispersible tablets was simple and rapid, which could be as dissolution detection method of evodiamine dispersible tablets; Evodiamine was almost insoluble in water, but ultrafine grinding combined with solid dispersion technology could significantly improve dissolution of it.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第24期32-34,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
四川省科技计划项目(2009SZ0233)
关键词
吴茱萸碱分散片
吴茱萸碱
不同处理方法
溶出度
evodiamine dispersible tablets
evodiamine
different processing methods
dissolution
