摘要
目的 研究健康志愿者po利福平胶囊 (0 .6 g)的药动学。 方法 高效液相色谱法测定人血清中利福平及其代谢物 ,薄层色谱分离代谢物 ,以二极管阵列检测器进行定性。结果 利福平的体内过程符合具有一级吸收的二房室模型 ,其主要药动学参数t1/ 2 β,tmax,cmax及AUC分别为 (5 .17± 2 .10 )h ,(1.84± 0 .6 8)h ,(7.84± 4.86 ) μg·ml-1,(12 6 .6 7± 34 .0 2 ) μg·h·ml-1,利福平体内代谢物主要为 2 1 脱乙酰利福平 ,血清中 2 1 脱乙酰利福平浓度较长时间维持在 4μg·ml-1以上。
OBJECTIVE To study the pharmacokinetics of rifampin capsules in healthy volunteers after a high oral dose of 0.6 g.METHODS The serum drug concentration was determined by HPLC.The metabolite of rifampin was separated by TLC and identified by DAD detector.RESULTS The pharmacokinetics of rifampin was fitted to a two compartment model with first order absorption.The t 1/2β , t max , c max and AUC of rifampin were (5.17±2.10)h,(1.84±0.68)h,(7.84±4.86)μg·ml -1 ,(126.67±34.02)μg·ml -1 ·h,respectively.The metabolite of rifampin in human body was 21 desacetylrifampin.Its serum concentration was over 4 μg·ml -1 for a long time.CONCLUSION The study presented some useful information for clinical trails.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2000年第6期396-398,共3页
Chinese Pharmaceutical Journal
关键词
高效液相色谱法
利福平
药物动力学
high performance liquid chromatography
rifampin
21 desacetylrifampin
pharmacokinetics
