摘要
目的 :研究不同剂量氟哌啶对曲马多病人自控硬膜外镇痛 (PCEA)效应及副作用的影响。方法 :择期手术 3 2 0例随机分成四组 ,A组 (n =80 ) :1%曲马多 +0 .15 %丁哌卡因 (对照组 ) ;B组 (n =80 ) :1%曲马多 +0 .15 %丁哌卡因 +0 .0 0 5 %氟哌啶 ;C组 (n =80 ) :1%曲马多 +0 .15 %丁哌卡因 +0 .0 1%氟哌啶 ;D组 (n =80 ) :1%曲马多 +0 .15 %丁哌卡因 +0 .0 15 %氟哌啶。上述各组按比例配制 ,总容量为 10 0ml装入Graseby 93 0 0微电脑PCA泵 ,持续镇痛 2 4小时。结果 :B、C、D三组镇痛效果均满意且优于A组 (P <0 .0 5 ) ;随着氟哌啶剂量的增加 ,恶心呕吐并发症呈显著性减少(P <0 .0 1) ,嗜睡则有增多的趋势。结论 :氟哌啶对曲马多PCEA效果有增强作用 ,以中等剂量氟哌啶 ( 0 .0 1% )配伍 1%曲马多更为有效 ,副作用较少 ,可作为PCEA配方在临床选择应用。
Aim: To study the clinical effects and aversive side effects of different dosage of droperidol on the post operative patient control epidural analgesia (PCEA) with tramadol. Methods: 320 patients scheduled for postoperative PCEA were randomly and evenly divided into four groups of 80 each. Group A: 1% tramadol +0.15% bupivacaine(control group); group B: 1% tramadol + 0.15% bupivacaine + 0.005% droperidol; group C: 1% tramadol +0.15% bupivacaine+0.010% droperidol; group D: 1% Tramadol+0.15% bupivacaine+0.015% droperiol. All patients were taken PCEA for 24 hours with Graseby 9300 microcomputer infusion PCA pump. Results: The analgesic effects of group B, C and D were satisfactory and better than that of group A ( P <0.05).The occurrence of nausea and vomitting was decreased ( P <0.01) and the somnolence rate were increased along with the increase of the droperidol concentration. Conclusion: Moderate dosage of droperidol (0.01%) is beneficial for post operative pain control using PCEA with tramadol and is effective in decreasing the occurrence of aversive side effects such as nausea and vomitting.
出处
《中国疼痛医学杂志》
CAS
CSCD
2000年第2期79-82,共4页
Chinese Journal of Pain Medicine
