摘要
采用高效液相色谱法测定哺乳妇女单剂量静滴甲硝唑 ( 2 0mg/kg ,n =8)、替硝唑 ( 1 3mg/kg ,n =7)乳汁药物浓度 ,色谱柱为 pecoshereC1 8( 3μm ,3.3cm× 4.6mm) ,氯仿提取乳汁中药物 ,其平均回收率大于 88.8% .乳汁中甲硝唑与替硝唑药代动力学参数tmax,Cmax,t1 / 2Ke分别为 1 .7± 1 .0h ,2 0 .1 0± 4.95μg/mL ,6.4± 3.3h和 1 .3±0 .6h ,1 7.2 3± 3.1 2 μg/mL ,1 1 .0± 3.5h .
The metronidazole and tinidazole in human breast milk were assayed by high performance liquid chromatography(HPLC). A high performance and rapid column pecosphere C\- 18 (3 μm, 3.3 cm×4.6 mm) was used. Metronidazole and tinidazole in breast milk extracted with chloroform, the average recovery rates from breast milk were above 88.8 %. The pharmacokinetic parameters(mean±s) t\- max , c\- max , t\- 1/2ke of Metronidazole and Tinidazole in lactating women after infusion of a single dose of Metronidazole(20 mg/kg, n=8) and Tinidazole (13 mg/kg, n=7) respectively were 1.7±1.0 h, 20.10±4.95 μg/mL, 6.4±3.3 h and 1.3±0.6 h, 17.23±3.12 μg/mL, 11.0±3.5 h.
出处
《分析测试技术与仪器》
CAS
2000年第2期112-114,共3页
Analysis and Testing Technology and Instruments
