摘要
目的:考察盐酸奈必洛尔原料药中催化剂钯的残留量。方法:采用电感耦合等离子体发射光谱法,测定波长为340.458nm,以微波消解法进行样品前处理,并将测定结果与石墨炉原子吸收光谱法比较。结果:在10～100 ng.mL-1的浓度范围内,钯的发射强度与浓度呈良好的线性关系,重复性试验的RSD为1.6%,加样回收率为94.2%,检测限为0.5μg.g-1。结论:该法可作为石墨炉原子吸收法的替代或补充,可用于原料药中催化剂钯的残留量测定。
Objective：To determine the residue amount of palladium which was used as a catalyst in drug sub- stances of nebivolol hydrochloride. Methods： An inductively coupled plasma atomic emission spectrometry method was established and the detection wavelength was 340. 458 nm. Microwave digestion was used for sample pretreat- ment. The determination results were compared with those by graphic furnace atomic absorption spectrometry. Re- suits ：The emission intensity and the concentration showed a good linear relationship in the 10 - 100 ng · mL^-1 con- centration range,with the relative standard deviation of repeatability 1.6%, the recovery 94.2%, and the limit of detection 0. 5 μg · g^-1. Conclusion：The method can be used for the determination of catalyst palladium residues in drug substances, as GFAAS method＇s alternative and complementary.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2012年第12期2226-2228,共3页
Chinese Journal of Pharmaceutical Analysis
