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生酮饮食治疗药物难治性癫癎的腺苷机制 被引量：2

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摘要 生酮饮食即高脂、低碳水化合物和适当蛋白质饮食疗法，是由美国梅奥诊所的Wilder首次于1921年提出并应用于临床治疗药物难治性癫癎；白1939年抗癫癎药物苯妥英问世至20世纪末，由于经典的抗癫癎药物不断涌现，加之生酮饮食制作相对复杂，人们对饮食治疗的兴趣就减退了；1998年约翰·霍普金斯医院报道了生酮饮食对治疗难治性癫癎患儿具有显著疗效，生酮饮食治疗后6个月，
作者 李天富 栾国明
机构地区 北京三博脑科医院癫痢中心神经内科 北京三博脑科医院癫痢中心神经外科
出处 《中华儿科杂志》 CAS CSCD 北大核心 2012年第12期903-905,共3页 Chinese Journal of Pediatrics
基金 国家自然科学基金（81171288）
关键词 药物难治性癫痫 生酮饮食 饮食治疗 抗癫痫药物 腺苷 低碳水化合物 饮食疗法 临床治疗
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献38

  • 1Wilder RM. The effects of ketonemia on the course of epilepsy. Mayo Clin Proc, 1921, 2:307-308.
  • 2Freeman JM, Vining EP, Pillas DJ, et al. The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children. Pediatrics, 1998, 102: 1358-1363.
  • 3Henderson CB, Filloux FM, Alder SC, et al. Efficacy of the ketogenic diet as a treatment option for epilepsy: meta-analysis. J Child Neurol, 2006, 21:193-198.
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同被引文献25

  • 1Li B,Tong L,Jia G. Effects of kctogcnic diet on the clinical and electroencephalographic features of children with drug therapy resistant epilepsy[J].Exp Tber Med,2013,(02):612-615.
  • 2Danial NN,Hartmn AL,Stafstorm CE. How does the ketogenic dict work? Four potential mechanisms[J].Journal of Child Neurology,2013,(08):1027-1033.
  • 3Kim YS,Choi MY,Ryu JH. Clusterin interaction with Bcl-xL is associated with scizurc-induced ncuronal dcath[J].Epilcpsy Res,2012,(03):240-251.
  • 4Holtzman DM. In vivo effects of ApoE and clusterin on amyloid-bctametabolism and neuropathology[J].Journal of Molecular Neuroscience,2004,(03):247-254.
  • 5Ziegler DR,Araújo E,Roua LN. A ketogenic diet increases protein phosphorylation in brain sliccs of rats[J].Journal of Nutrition,2002,(13):483-487.
  • 6Haut SR,Vcliskova J,Moshc SL. Susceptibility of immature and adult brains to seizure effects[J].Biological Psychiatry,2004,(10):608-617.
  • 7Ni H,Feng X,Gong Y. Acute phase expression pallern of ZnTs,LC3,and beclin-1 in rat hippocampus and its regulationby 3-Methyladenine following recurrent neonatal seizures[J].Biological Trace Element Research,2011,(01):320-331.
  • 8Sogawa Y,Monokoshi M,Silveira DC. Timing of cognitive deficits following neonatal scizures:relationship to histological changes in the hippocampus[J].Developmental Brain Research,2001,(1-2):73-83.
  • 9Gibbs S,Chattopadhyaya B,Desgent B. Long-term consequences of a prolonged febrile seizure in a dual pathology model[J].NEUROBIOLOGY OF DISEASE,2011,(02):312-321.
  • 10Ni H,Yan JZ,Zhang LL. Long-term effects of recurrent neonatal seizures on neurobehavioral function and related gene expression and its intervention by inhibitor of Cathepsin B[J].Neurochcm Res,2012,(01):31-39.

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中华儿科杂志
2012年 第12期

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