摘要
目的探讨p53蛋白在幼年型复发性呼吸道乳头状瘤病(JO-RRP)中的表达及其诊疗意义。方法收集耳鼻咽喉科诊断并经病理证实的JO-RRP病例11例作为治疗组,5例正常喉组织标本作为对照组。全部病例初诊及复诊所送组织均以免疫组化SP法检测p53蛋白。结果 p53蛋白在JO-RRP中的表达均数为(14.2±2.5)%,在正常喉组织中的表达均数为(3.0±0.8)%,两者比较,有显著性差异(P=0.03);不同乳头状瘤标本中p53蛋白表达各异,治愈组与复发组、侵袭组间比较,有显著性差异(P<0.05),侵袭组与复发组之间比较,无显著性差异(P>0.05)。结论 p53蛋白的异常表达所致的细胞凋亡障碍促进了复发性呼吸道乳头状瘤的生长,这种因子也为JO-RRP的靶向治疗提供了可能的途径。
Objective To investigate the expression and its clinical significance of p53 in juvenile onset recurrent respiratory papillomatosis（JO-RRP）. Methods The data with the diagnosis of JO-RRP from 2008 to 2012 in our hospital were analyzed, 11 cases were devided into the treatment group which were confirmed by pathology, 5 cases of normal laryngeal tissue specimens were as controls. Reviews were done on clinical history and histological sections. All cases of newly diagnosed and referral to send tissue by immunohistochemistry SP method for detection of p53 protein. Results The expression of p53 were： RRP 14.2±2.5%, normal laryngeal tissue 3.0% ±0. 8%, P= 0. 03 , there was significance of p53 Protein expressions between two groups（P〈0. 05） different papilloma specimens in different p53 protein expressions, there was significance of p53 Protein expressions between cure group and relapsed group or aggressive group （P〈0.05） ,there was no significance of p53 Protein expressions between relapsed group and aggressive group（P〉0.05） Conclusion P53 protein expression of the apoptosis induced by obstacles to promote recurrent respiratory papillomatosis growth, this factor provides a possible way for JO-RRP targeted therapy
出处
《西部医学》
2012年第12期2266-2268,共3页
Medical Journal of West China
