摘要
目的:观察了氟比洛芬酯联合吗啡镇痛对食管癌患者血清Th1/Th2细胞因子的影响。方法:60例择期全麻下行食管癌根治术患者随机分为氟比洛芬酯组(A组)和吗啡组(B组),每组30例。分别于术前0.5h静注氟比洛芬酯或安慰药英脱利匹特,术后距第1次给药6h再次静注氟比洛芬酯或英脱利匹特。两组患者均行患者自控静脉镇痛(PCIA)。于麻醉前,手术开始后2h、6h、24h分别应用放免法和酶联法测定γ干扰素(IFN-γ)和白细胞介素-4(IL-4)浓度。结果:与麻醉前比较,两组IFN-γ、IL-4水平在术后2h、6h均明显升高(P<0.05)。术后24h仍未恢复至麻醉前水平(P<0.05)。与B组比较,A组IL-4、IFN-γ升高幅度较小。结论:食管癌根治术围术期用氟比洛芬酯联合吗啡镇痛较单用吗啡镇痛可降低血清IFN-γ、IL-4水平,从而具有重要的临床价值。
Objective To observe the effects of postoperative analgesia with flurbiprofen axetil combined with morphine on serum IFN-γ,IL-4 levels in patients with esophageal cancer.Methods 60 cases undergoing elective esophageal cancer surgery under general anesthesia were randomly allocated into flubiprofen axetil group（A） and morphine group（B） with 30 cases each.The patients in group A and B received intravenous flubiprofen axetil and placebo（intralipid） 30min before surgery,respectively,which were repeated at 6h later.All patients received patient-controlled intravenous analgesia（PCIA） postoperatively.Serum IFN-γ,IL-4 levels were measured by RIA or ELISA at 3 time points：Before anesthesia baselines at 2h after incision 6h,24h after operation.Results Compared with the baselines,the serum IFN-γ,IL-4 in both groups increases at 2h after incision,6h and 24h after operation（P0.01）.The value of levels IFN-γ,IL-4 even did not return to the baseline at 24h after operation（P0.05）.Serum IFN-γ,IL-4 were less in group A than in group B at 2h after incision and 24h after operation.Conclusion The protective effect of PCIA with flubiprofen axetil combined with morphine could reduce of serum IFN-γ,IL-4 levels in patients with esophageal cancer and thus possess of important clinical values.
出处
《放射免疫学杂志》
CAS
2012年第6期621-623,共3页
Journal of Radioimmanology
关键词
食管癌
氟比洛芬酯
吗啡
干扰素-Γ
白细胞介素-4
esophageal cancer operation
flurbiprofen axetil
morphine
interferon-γ（IFN-γ）
interleukin-4（IL-4）
