摘要
目的探讨血清降钙素原（procalcitonin，PCT）测定在重症监护病房（ICU）重度有机磷中毒患者医院感染中的临床意义。方法选取重度有机磷中毒患者107例，采用半定量固相免疫色谱法（PCT—Q）动态监测血清PCT浓度，同时分析医院感染的情况。结果ICU重毒有机磷中毒患者医院感染率为43．8％，感染组与对照组血清PCT浓度比较差异有统计学意义（P〈0．01），PCT〉0．5ng／ml预测医院感染的敏感度、特异度、阳性预测值、阴性预测值分别为95．65％、81．83％、80％、96．15％。对PCT阳性患者使用适当抗生素治疗3—7d后，PCT转为正常（〈0．5ng／m1）。结论血清降钙素原测定对ICU重毒有机磷中毒患者院内感染早期诊断及临床抗生素治疗有指导意义。
Objective To explore the clinical significance of serum procalcitonin （PCT） levels in severe organophosphorus poisoning patients with nosocomial infection in ICU. Methods One hundred and seven patients were selected and monitored PCT concentration using semiquantitative solidphase im- mune ehomatography（PCT-Q） and nosocomial infection. Results The rate of nosocomial infection was 43 % in severe organophosphorus poisoning patients. The difference of PCT concentration was statistically significant （ P 〈 0.01 ） between infection group and control group. The sensitivity, specificity, and posi- tive and negative predictive values of nosocomial infection prediction with PCT 〉0. 5 ng/ml were 95.65% ,81.83% ,80% and 96.15% , respectively. PCT values returned to normal（ 〈0, 5 ng/ml） by 3 to 7 days of appropriate antibiotic therapy. Conclusions For severe organophosphorus poisoning patients in ICU, monitoring PCT level could help find and distinguish nosocomia] infection at an earlier stage and guide the application of antibiotics.
出处
《中国实用医刊》
2012年第23期49-51,共3页
Chinese Journal of Practical Medicine
关键词
降钙素原
医院感染
ICU
重度有机磷中毒
Procalcitonin
Nosocomial infection
ICU
Severe organophosphorus poisoning
