摘要
研究了以吡啶为缩合剂,通过苯甲醛与丙二酸的Knoevenagel缩合反应合成肉桂酸的路线,以产物的收率作为考察指标,采用单因素多水平方法,分别研究了反应物配比、缩合剂用量、反应温度、反应时间等因素对收率的影响,确定了最佳工艺条件。最佳工艺条件下的肉桂酸收率达95%以上,并采用红外光谱对目标产物结构进行表征。该路线具有工艺简单,产率高,反应污染小,产物分离纯化容易,操作方便等优点。
The characters of the paths were summarized,and the path of using pyridine as condensation agent,benzaldehyde and malonic acid by Knoevenagel condensation reaction was mainly studied.By using the method of single-factor and multi-levels,the yield of cinnamic acid as an index,the reaction conditions such as catalyst ratio,reactant ratio,reaction temperature,reaction time were examined to give the preferable process.In the preferable process,the yield of cinnamic acid was 95%.The result was characterized by infrared spectrum and the structure was verified with HPLC.This path was simple,with high yield and less pollution.
出处
《广州化工》
CAS
2012年第22期94-95,135,共3页
GuangZhou Chemical Industry
