摘要
目的:探讨正常人群外周血清中sDR5及与肺癌患者的差异。方法:采用ELISA夹心法检测106例正常人群、79例肺癌患者与肺癌化疗以后血清中死亡受体5的含量,并运用SPSS软件对其结果进行统计学分析。结果:正常人群外周血清中sDR5平均值为(6.25±3.09)μg/L,肺癌患者的sDR5含量为(53.91±13.42)μg/ml明显高于正常人群,P<0.001。肺癌病人化疗后外周血sDR5水平为(23.99±14.23)μg/ml较治疗前明显下降,P<0.001。结论:外周血中sDR5的消退水平有可能与肿瘤病人发病、发展及预后密切相关。
Objective：To investigate the difference of periphery serum sDR5 between healthy adults and lung cancer patients.Methods：The value of sDR5 were detected by ELISA method in 106 healthy adults and 79 lung cancer patients,the results of which were analyzed via SPSS13.0 software.Results：The mean of sDR5 was（6.25±3.09） μg/L in periphery serum of healthy adults,and the value of periphery serum sDR5 in lung cancer patients（53.91±13.42） μg/ml was obviously higher than that of the healthy adults（6.25±3.09） μg/L,（P0.001）,which reduced to（23.99±14.23） μg/ml after chemical therapy.Conclusion：The decrease level of sDR5 in the lung cancer may be related to the severeness,the effectiveness of the treatment and the prognosis of lung cancers.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2012年第11期1028-1031,共4页
Chinese Journal of Immunology
基金
河南大学大学生创新项目资助课题
关键词
死亡受体5
夹心ELISA
肺癌
Death receptor 5
Double antibodies sandwich ELISA
Lung cancer
