摘要
目的探讨XIAP及c-jun在原发性肺癌组织中的表达水平及其临床意义。方法选用组织芯片应用免疫组化S-P法检测XIAP、c-jun蛋白在正常肺组织、肺良性病变、肺癌旁组织和原发性肺癌组织中的表达。结果 XIAP、c-jun在肺癌组织中的阳性表达率均明显升高,恶性组显著高于正常组、良性组和癌旁组(P<0.05),XIAP、c-jun在肺癌临床晚期(Ⅲ期和Ⅳ期)组的阳性表达水平(MOD值)均明显高于临床早期(Ⅰ期和Ⅱ期)组(P<0.05),XIAP、c-jun的阳性表达水平在有淋巴结转移组均高于无淋巴结转移组(P<0.05),XIAP与c-jun在肺癌组织中阳性表达呈正相关(r=0.232,P<0.05),术后生存期小于1年患者的XIAP、c-jun阳性表达率均明显高于生存期超过1年患者(P<0.05)。XIAP、c-jun的MOD值与患者性别、年龄、肿块直径和组织学类型均无关(P>0.05)。结论 XIAP、c-jun蛋白阳性水平的高表达提示患者预后较差,联合检测XIAP、c-jun蛋白阳性表达水平可作为临床诊断及患者预后预测的参考指标。
Objective To investigate the expression levels and clinical significance of X-linked inhibitor of apoptosis protein （XIAP） and c-jun in primary lung cancer tissues. Methods Immunohistochemical SP method was used to detect the expression levels of XIAP and e-jun in normal lung tissues, lung benign lesions, adjacent tissues of lung cancer and primary lung cancer tissues. Results The positive expression rates of XIAP and c-jun in the primary lung cancer tissues were significantly higher than those in the normal lung tissues, lung benign lesions and adjacent tissues of lung cancer （P 〈 0.05 ）. The positive expression levels （ MOD value） of XIAP and e-jun in advanced lung cancer tissues （ Stage Ⅲ and Ⅳ ） were significantly higher than those in the early-stage lung cancer tissues （ Stage Ⅰ and Ⅱ ） （P 〈 0.05 ）. The positive expression levels of XIAP and e-jun in the lung cancer tissues with lymph node metastasis were significantly higher than those in the lung cancer tissues without lymph node metastasis （P 〈 0.05 ）. The positive expression levels （MOD value） of XIAP and e-jun were positively correlated in the lung cancer tissues （ r = 0. 232, P 〈 0.05 ）. The positive expression levels of XIAP and e-jun in the patients with postoperative survival time less than 1 year were significantly higher than those in the patients with postoperative survival time more than 1 year （ P 〈 0.05 ）. The positive expression levels （MOD value） of XIAP and c-jun were not correlated with patients＇ age, sex, tumor diameter or histopathologieal type （ P 〈 0.05 ）. Conclusion High expression of XIAP and c-jun indicates poor prognosis of patients with lung cancer. XIAP and c-jun expression levels can be used as reference indices for clinical diagnosis and prognosis prediction in patients with lung cancer.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2012年第23期2408-2410,共3页
Journal of Third Military Medical University
基金
贵州省科学技术基金资助项目[黔科合J字(2007)2128]~~
