摘要
目的探讨不同阶段肝炎后肝硬化患者当中骨营养不良的发病情况为相关并发症的防治提供理论依据。方法选择代偿性肝硬化(Child-Pugh A级)组55例,失偿性肝硬化(Child-Pugh B、C级)组35例,作为研究对象组,所选人群均为男性住院且排除肾脏疾病及内分泌系疾病。普通男性健康人群数量45名,所选人群均排除肝病、肾脏疾病及内分泌系疾病。检测Ca2+、血清甲状旁腺素(PTH)及降钙素(CT)、碱性磷酸酶同工酶(ALP3)、左侧桡骨下1/3处骨密度值,分别作对照。结果研究对象组随着病变的严重程度存在明显的血钙水平偏低,并且伴有血清甲状旁腺素升高而降钙素水平相对偏低,骨源性ALP3明显高于对照组,骨密度降低。结论不同阶段肝硬化患者普遍存在不同程度的骨吸收增加、骨形成下降的情况,主要表现为骨营养不良及骨质疏松症。
Objective The objective of this paper is to probe into osteoporosis disease incidence of cirrhosis after hepatitis patients,providing theory evidence to the prevention and cure of related complicating disease.Methods Select 90 male patients who are diagnosed as cirrhosis by hepatology professor of our hospital as random sample to research.all of whom are excluded the possibility of having kidney and endocrine disease.Simultaneously,randomly select 45 healthy males who coming to our hospital to do physical examination,and all of them are excluded the possibility of having hepatology,kidney and endocrine disease.Collect venous blood specimen from every patients from object group and control group to test Ca2 ＋,PTH,CT,ALP3 volume and the volume of left radius（at the 1、3 position） bone mineral density.Compare the volume of every patient from object group and control group.Results The comparison is that the level of blood calcium of patients from object group is obviously lower,furthermore the blood serum parathyroid hormone is higher and calcitonin is lower.The volume of ALP3 of patients diagnosed as cirrhosis is obviously higher than of patients from control group.Conclusion Cirrhosis patients in Jilin have increasing bone resorption and decreasing bone formation is a general condition.
出处
《中国实用医药》
2012年第30期25-26,共2页
China Practical Medicine
关键词
肝硬化
骨密度
骨质疏松症
Cirrhosis
Bone mineral
Density osteoporosis
