摘要
核苷(酸)类似物(NUCs)和干扰素(IFN)α是目前临床上主要用于治疗乙型肝炎和丙型肝炎的药物。考虑到HBV对已有的NUCs均具有耐药现象,且疗程漫长,同时IFNα疗效有限,不良反应大,故开发新的靶位/作用环节的药物具有重要意义。本文就目前发现的一些具有抑制HBV和HCV复制而无严重肝毒性的中草药化学药物做一综述。
Nucleus（t）ide analogs and interferon remain the principal drugs used to treat infections with hepatitis B and hepatitis C worldwide.While the nucleus（t）ide analog regimen may be more effective than interferon,it uses a long treatment course and development of drug resistance is frequent.Therefore,there is an urgent need to identify and institute alternative therapeutic approaches that overcome the limitations of these current drugs.In this review,we present the drugs from Chinese medicine that are capable of suppressing replication of hepatitis B virus and hepatitis C virus without producing serious liver damage and discuss the implications of developing these drugs for clinical use.
出处
《临床肝胆病杂志》
CAS
2012年第11期872-876,共5页
Journal of Clinical Hepatology
基金
国家"十一五"科技重大专项(2008ZX 10002-005)
关键词
中草药
肝炎病毒
乙型
肝炎病毒属
drugs
chinese herbal
hepatitis B virus
hepacivirus
