摘要
目的 观察顺铂缓释剂瘤内用药治疗大鼠C6胶质瘤的生物学效应。方法 用几丁质做载体 ,与顺铂制成缓释剂型 ,进行瘤内植入治疗大鼠脑胶质瘤。结果 瘤内给予 1mg/m2 顺铂缓释剂无毒性 ,瘤内铂浓度比全身用药高 2～ 5 0倍 ,维持时间达 1月以上 ,血铂浓度比全身用药低 10～ 6 0倍 ,荷瘤鼠生存时间较单纯顺铂液瘤内或全身用药明显延长。结论 瘤内给予顺铂缓释剂的抗肿瘤效果优于局部和全身单纯顺铂液给药。
Objective To examine the benefit of local delivery of cisplatin via chitin a biodegradable polymer in the treatment of intracranial glioma in rats compared against intratumorally administered free cisplatin and systemic cisplatin.Methods The C 6 glioma rat model and healthy controls were used to determine toxicity and efficacy of cisplatin loaded polymers. Tissue distribution of cisplatin was tested after that cisplatin impregnated chitin was administered intralesionally and free cisplatin was given by systemic administration.Results Intratumoral chemotherapy with polymer impregnated 1 0mg/m 2 cisplatin resulted in a significant longer survival time in the C 6 glioma rat model, compared with the group treated with intralesionally administered free cisplatin, and 50mg/m 2 cisplatin by systemic administration (P<0 001, respectively). Tumor concentrations were 2～50 times higher after intratumoural administration of cisplatin impregnated biodegradable polymers than i. p. administration of cisplatin. Plasma and kideny concentrations after intratumoral administrations were 10～60 and 60～200 times lower than those measured after i. p. administration, respectively.Conclusions The local implantation of cisplatin impregnated biodegradable polymer, allowing the sustained release of high dose chemotherapy locally is effective treatment for intracranial C 6 glioma in the rat.
出处
《中华神经外科杂志》
CSCD
北大核心
2000年第2期91-93,共3页
Chinese Journal of Neurosurgery
关键词
顺铂
几丁质
瘤内化疗
脑胶质瘤
药物疗法
Chitin Cisplatin Intratumoral chemotherapy Glioma Sustained release drug
