摘要
目的研究测定大骨节病患者和正常对照滑液中ＩＬ－１、ＴＮＦ的生物活性，试图为其发病机理提供一种思路。方法分别用Ｃ５７雌性小鼠胸腺细胞增殖法和１９２９细胞杀伤法进行ＩＬ－１和ＴＮＦ生物活性测定。结果大骨节病患者滑液中ＩＬ－１、ＴＮＦ生物活性高于正常对照组（Ｐ＜０．０５）。结论大骨节病发病过程中，ＩＬ－１、ＴＮＦ可能起着某种作用。
Objective to invesgate bioactivity of IL - 1 .TNF in synovial fluid of patients with Kashin - Beck disease. Methods IL- 1 was measured by thymocyte- activation facter assay, based on the ability of IL.- 1 to stimulate proliferation of C57 mouse thymocytes. INF was measured by cytotoxicity assay using L929 clone cells. Results Bioactivity of IL- 1 and TNF in KBD group is higher than normal control group. (P < 0.05) Conclusions IL- 1 and TNF maybe play some role in pathogene- sis of KBD.
出处
《中国地方病防治》
CAS
2000年第2期71-72,共2页
Chinese Journal of Control of Endemic Diseases
