摘要
目的 :检测阻塞性睡眠呼吸暂停综合征 (OSAS)合并慢性阻塞性肺病 (COPD)即重叠综合征(overlapsyndrome ,OS)患者血清中 β1-肾上腺素能受体与M2 -胆碱能受体自身抗体的变化。方法 :应用酶联免疫吸附法 (ELISA)检测OS患者 2 6例、OSAS患者 32例、COPD患者 30例及正常人 2 8例血清中抗 β1与M2 受体的自身抗体。结果 :β1与M2 受体的自身抗体阳性率及滴度 ,OS组 (92 2 % ,5 7 7%及 1∶98,1∶6 7)明显高于OSAS组 (71 9% ,40 6 %及 1∶83,1∶30 )和COPD组 (70 0 % ,36 7%及 1∶79,1∶2 8) (P <0 0 5 ) ,OSAS和COPD组显著高于正常对照组 (2 5 0 % ,14 3%及 1∶2 0 ,1∶2 0 ) (P <0 0 1)。结论 :OS ,OSAS与COPD患者血清 β1与M2 受体自身抗体明显高于正常人 。
AIM: To study the changes of serum autoantibodies against β 1- adrenergic and M 2-muscarinic receptors in obstructive sleep apnea syndrome (OSAS) patients with chronic obstructive pulmonary disease (COPD), that is, overlap syndrome (OS). METHOD: Serum autoantibodies against β 1 and M 2 receptors in 26 cases with OS, 32 with OSAS, 30 with COPD and 28 normal subjects were determined by using enzyme-linked immunosorbent assay(ELISA). RESULTS: The positive rates and titer of β 1 and M 2 receptor autoantibodies are significantly increased in OS group (92.2%,57.7% and 1∶98, 1∶67), compared to OSAS (71.9%, 40.6% and 1∶83, 1∶30) or COPD group (70.0%, 36.7% and 1∶79, 1∶28) (P<0.05), and they are higher in these groups than in the control (25.0%, 14.3% and 1∶20, 1∶20) (P<0.01). CONCLUSION:Serum β 1-and M 2 receptor autoantibodies are significantly increased in the patients with COPD, OSAS or OS, compared to the control, and the highest is in OS.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第3期255-257,共3页
Chinese Journal of Pathophysiology
关键词
呼吸暂停
综合征
阻塞性肺疾病
受体
自身抗体
Sleep apnea syndroms
Lung diseases
Obstructive
Receptors
adrenergic
beta
Receptors
cholinergic
Autoantibodies
