摘要
目的和方法 :本实验在大鼠主动脉球囊剥脱模型上 ,观察血浆和主动脉组织C -型利钠利尿肽(CNP)的动态变化及外源性CNP对大鼠球囊损伤后内膜生成的影响 ,以探讨CNP在再狭窄中的作用。结果 :发现大鼠球囊损伤后血浆CNP的浓度升高 ,内膜剥脱后第 3d、10d、2 1d ,血浆CNP水平分别增高 80 7% (P <0 0 1) ,43 5 % (P <0 0 5 )和 2 7 5 % (P <0 0 5 ) ,而主动脉组织CNP含量在损伤后第 3d下降 46 6 % (P <0 0 5 ) ,第10d ,2 1d和 2 8dCNP含量分别增加 2 8倍 (P <0 0 1)、1 6倍 (P <0 0 5 )和 0 82倍 (P <0 0 5 )。外源性CNP显著抑制球囊损伤后第 7d和 2 1d新生内膜的形成 ,内膜 /中膜比值分别降低 2 2 % (P <0 0 5 )和 2 0 % (P <0 0 5 )。结论 :CNP参与血管球囊损伤后的修复过程 ,外源性CNP可抑制内膜增厚。
AIM and METHODS: In a model of balloon injury of rat aorta, the dynamic changes of C-type natriuretic peptide (CNP) in plasma and aortic tissues and the effect of exogenous CNP on intima/media (I/M) ratios were studied. RESULTS:CNP levels in plasma were significantly increased by 80.7% (P<0.01),43.5%(P<0.05) and 27.5% (P<0.05) on 3 days, 10 days and 21 days after balloon injury, but its levels in aortic tissues were decreased by 46.6% (P<0.05) on day 3 and increased by 2.8 (P<0.01),1.6(P<0.05) and 0.82-fold (P<0.05) on day 10, day 21 and day 28 after balloon injury of rat aorta. Result also showed that the administration of CNP i.p. inhibited neointima formation. I/M ratios were decreased by 23% (P<0.05) and 20% (P<0.05) on 7 days, 21 days after balloon injury of rat aorta.CONCLUSION:CNP might be involved in the process of recovery after vascular endothelium-denudation and exogenous CNP suppress the neointima formation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第3期196-198,共3页
Chinese Journal of Pathophysiology
基金
九五国家科技攻关项目! 96 - 90 6 - 0 2 - 0 7
