摘要
通过对 1 1例重型肝炎病人中扩增的 HBV DNA直接序列分析 ,研究重型肝炎病人中 HBV C基因的变异及其特点。每个病例的 HBV C基因均有数量不等的变异 ,产生 1～ 1 2个氨基酸替代。慢性重型肝炎病人的 HBV C基因变异明显多于亚急性重型肝炎病人。C基因的变异呈聚集性 ,相对集中于 T淋巴细胞和 B淋巴细胞的抗原识别位点。重型肝炎病人的 HBV C基因有较高的变异率 ,在慢性重型肝炎的病人明显高于亚急性重型肝炎病人 ,变异相对集中于 T淋巴细胞和 B淋巴细胞抗原识别位点 。
Hepatitis B virus (HBV) core gene mutations were studied in 11 patients with fulminant hepatitis by direct sequencing. The results showed that there were at least 1 12 amino acid substitutions in each patient. In patients with chronic HBV infection there were significantly more variations than those of subacute fulminant cases. HBV core mutations occurred predominantly in known antigenic determinants, clustered between amino acid positions 35 60, 85 105 and 130 etc. The results indicate that mutation in HBV core gene is rather common, and HBV core gene variation are associated with chronic hepatitis progression and immune clearance.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2000年第1期8-10,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金!资助课题 (编号 3 963 0 2 80 )
