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大鼠神经轴索损伤erbB3 mRNA的表达(英文)

The Expression of ErbB3/Neu mRNA in Rat Axotomized Nerves
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摘要 神经生长调节因子 (Neuregulins)是一个多肽生长因子的家族 ,它对神经雪旺氏细胞具有重要作用 .我们调查了大鼠雪旺细胞神经生长因子受体的调节作用 ,发现在成年鼠的坐骨神经中 ,erbB3mRNA的表达随神经轴索损伤程度而增加 ,通过去除神经轴索上的雪旺细胞表达增加 .结论 :神经生长调节因子erbB3mRNA受体的表达是通过轴索 -雪旺氏细胞的相互作用调节完成 . Neuregulins are a family of peptide growth factors with potent effects on Schwann cells. We have investigated the regulation of erbB3/neu,which form the neuregulin receptor of rat Schwann cells. In the adult sciatic nerve,the expression of erbB3 mRNA increases in parallel following axotomy. ErbB3 mRNA is expressed by denervated Schwann cells in axotomized nerves.So,the expression of erbB3 mRNA is regulated by axon-Schwann cell interactions.
作者 李明 苏姗 史蒂文.谢勒
机构地区 昆明医学院解剖教研室 宾夕法尼亚大学医学院神经科
出处 《昆明医学院学报》 2000年第1期25-28,共4页 Journal of Kunming Medical College
基金 This work was supported by grants from the NIH!NS0 80 75,NS0 156 5
关键词 神经轴索损伤 坐骨神经 ERBB3 MRNA erbB3 axon-Schwann cell interactions axotomy rat nerve
分类号 R651.302 [医药卫生—外科学]
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参考文献10

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昆明医学院学报
2000年 第1期

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