摘要
目的探讨血清肿瘤标志物癌胚抗原(CEA)、神经烯醇化酶(NSE)、基质金属蛋白酶-9(MMP-9)联合检测在肺癌诊断中的应用价值。方法选择住院确诊肺癌患者124例,肺部良性病变45例,健康体检者65例,检测三组对象血清NSE、CEA和MMP-9的水平,应用受试者工作曲线(ROC)评价联合检测的诊断效果。结果 (1)血清NSE水平随小细胞癌、腺癌、鳞癌、良性肿瘤、健康者依次降低,其中小细胞癌患者血清NSE水平显著高于其他组(P<0.01);而MMP-9与CEA水平在腺癌患者血清中水平最高(P<0.01);(2)绘制ROC曲线,血清NSE诊断小细胞肺癌的敏感性为80.1%,特异性71.1%,曲线下面积为0.84;MMP-9与CEA联合检测诊断肺癌的敏感性为92.7%,特异性为84.4%,曲线下面积0.95,联合检测显著优于单项检测。结论血清CEA、NSE、MMP-9等肿瘤标志物在肺癌患者中普遍增高,联合检测可以显著提高肺癌诊断的敏感性和特异性。
Objective To evaluate the effects of combined detection of serum tumor markers CEA, NSE and MMP-9 in di- agnosis of lung cancer. Methods A total of 124 cases of lung cancer, 45 benign lung lesions and 65 healthy people were selected in our hospital. The serum tumor marker of NSE, CEA and MMP-9 levels were detected in the three groups and the receiver operating curve （ROC） was used to evaluate the diagnosis test. Results （l）The level of serum NSE was de creased in the order of small cell carcinoma, adenocarcinoma, squamous cell carcinoma, benign tumor group and healthy people, in which the NSE level in patients with small cell carcinoma was significantly higher than that in other groups （P 〈 0.01）. The MMP-9 and CEA were much higer in the adenocarcinoma （P 〈 0.01 ）; （2）Plotting ROC curves, the sensitivity, specificity and the area of ROC for serum NSE in small cell carcinoma were 80.1%,71,1% and 0.84 respectively; The MMP-9 and CEA combined detection in diagnosis of lung cancer had sensitivity of 92.7%, specificity of 84.4% and area of ROC 0.95. Conclusion The serum tumor marker CEA, NSE, MMP-9 are usually elevated in lung cancer. Combined de- tection of the tumor markers can improve the sensitivity and specificity for diagnosis of lung cancer.
出处
《中国现代医生》
2012年第32期54-55,共2页
China Modern Doctor
关键词
肺癌
肿瘤标志物
诊断
Lung cancer
Tumor marker
Diagnosis
