摘要
目的:探讨质子泵抑制剂(PPI)预防脑出血后应激性胃肠黏膜病变与并发艰难梭菌相关性腹泻(CDAD)的关系。方法:采用随机数字表法将180例脑出血患者分为2组,对照组给予脑出血常规治疗,奥美拉唑治疗组除常规治疗外,在住院第1天即给予奥美拉唑治疗。观察2组脑出血患者应激性胃肠黏膜病变和CDAD的发病率。结果:2组应激性胃肠黏膜病变发病率差异无统计学意义(χ2=3.33,P>0.05);奥美拉唑治疗组CDAD发病率高于对照组(χ2=4.74,P<0.05)。结论:脑出血患者常规给予PPI预防应激性胃肠黏膜病变不能降低其发病率,反而会增加CDAD的发病率。
OBJECTIVE： To explore the relationship between proton pump inhibitors （PPI） preventive treatment for stress gastrointestinal mucosal lesions in the intracerebral hemorrhage patients and Clostridium difficile-associated diarrhea （CDAD）. METHODS： 180 intracerebral hemorrhage patients were randomly divided into 2 groups. Omeprazole preventive treatment group were given omeprazole in the first day of hospitalization besides conventional treatment for intracerebral hemorrhage, and the control group were only given conventional treatment. The incidence of stress gastrointestinal mucosal lesions and CDAD in the intracerebral hemorrhage patients in 2 groups was observed. RESULTS： The incidence of stress gastrointestinal mucosal lesions was not different between 2 groups （χ2=3.33,P0.05）. The incidence of CDAD in omeprazole preventive treatment group was higher than in control group （χ2=4.74,P0.05）. CONCLUSION： PPI preventive treatment for stress gastrointestinal mucosal lesions in the intracerebral hemorrhage patients will not decrease its incidence, but increase the incidence of CDAD.
出处
《中国药房》
CAS
CSCD
2012年第46期4376-4378,共3页
China Pharmacy
关键词
脑出血
艰难梭菌相关性腹泻
应激性胃肠黏膜病变
质子泵抑制剂
Intracerebral hemorrhage
Clostridium difficile-associated diarrhea
Stress gastrointestinal mucosal lesions
Proton pump inhibitors
