摘要
目的:了解我院应用特殊使用类抗菌药物的住院患者的细菌分布特点及耐药情况。方法:抽取我院2011年7-12月应用特殊使用类抗菌药物的200例住院患者,对其细菌培养及药敏试验结果进行回顾性分析。结果:治疗用药病原学送检率达95.0%,阳性率为52.6%;检出菌株数排名前5位的分别为金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌、大肠埃希菌。其中耐甲氧西林金黄色葡萄球菌(MRSA)占80.6%,肺炎克雷伯菌及大肠埃希菌产超广谱β-内酰胺酶(ESBLs)率分别为54.5%和60.0%,鲍曼不动杆菌对碳青霉烯类抗菌药物的耐药率>50%,铜绿假单胞菌对亚胺培南/西司他丁和美罗培南的敏感率均为66.7%。结论:我院应用特殊使用类抗菌药物住院患者的检出菌株均为院内感染常见的致病菌,且耐药情况严重,应引起足够重视。
OBJECTIVE： To investigate pathogens distribution and the present status of drug-resistance in the inpatients with antibiotics for special use from our hospital. METHODS： 200 inpatients with antibiotics for special use were collected from our hospital randomly during Jul.-Dec. in 2011. Bacterial culture and the antibiotic sensitivity tests were analyzed by a retrospective investigation. RESULTS： The aetiology detection rate was 95.0%, and the positive rate was 52.6%; Staphylococcus aureus, Klebsiella peumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli were the top 5 causes. Among them, methicillin-resistant Staphylococcus aureus （MRSA） accounted for 80.6%; K. peumoniae and Escherichia coli producing extended-spectrum （ESBLs） accounted for 54.5% and 60.0%, respectively; the resistance rate of A. baumannii to carbapenems was beyond 50%, and the sensitive rates of P. aeruginosa to imipenem/cilastatin and meropenem were 66.7%. CONCLUSION： Bacterial strains of inpatients with antibiotics for special use in our hospital are the common pathogens of nosocomial infection. The severe situation of drug resistance should be paid enough attention.
出处
《中国药房》
CAS
CSCD
2012年第46期4366-4369,共4页
China Pharmacy
关键词
特殊使用类抗菌药物
细菌耐药
调查分析
Antibiotics for special use
Bacterial resistance
Analysis of investigation
