摘要
目的:比较儿童与成人常见病原菌耐药状况。方法:监测2010年度泉州市儿童医院与泉州市第一医院临床分离细菌的耐药状况,以WHONET5.5软件进行数据分析,比较儿童与成人临床常见病原菌的耐药性差异。结果:由儿童患者分离得到致病菌1815株,其中革兰阳性菌767株(占42.3%),革兰阴性菌1048株(占57.7%);最常见的细菌依次为肺炎克雷伯菌、大肠埃希菌、金黄色葡萄球菌、流感嗜血杆菌、铜绿假单胞菌、鲍曼不动杆菌。由成人患者分离得到致病菌2345株,其中革兰阳性菌768株(占32.8%),革兰阴性菌1577株(占67.2%);最常见的细菌依次为大肠埃希菌、鲍曼不动杆菌、肺炎克雷伯菌、金黄色葡萄球菌、肠球菌、铜绿假单胞菌。儿童和成人耐甲氧西林金黄色葡萄球菌(MRSA)的检出率分别为19.8%和17.8%;儿童患者大肠埃希菌和肺炎克雷伯菌对阿米卡星和喹诺酮类药的耐药率要远低于成人;儿童患者铜绿假单胞菌和鲍曼不动杆菌对抗菌药物的耐药率低于成人,特别是对氨基糖苷类和喹诺酮类药。结论:儿童患者常见病原菌分布和耐药特点与成人存在一定的差异;应持续地进行细菌耐药监测。
OBJECTIVE： To compare the drug resistance of common pathogens between children and adults. METHODS： All of the bacterial susceptibility results from Quanzhou Children’s Hospital and Quanzhou First Hospital in 2010 were analyzed by WHONET 5.5 software. Drug resistances of common pathogens were compared between children and adults. RESULTS： A total of 1 815 bacterial isolates were collected from children,which included 1 048（57.7%） strains of Gram-negative bacteria and 767 （42.3%） strains of Gram-positive bacteria; Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, Pseudomonas aeruginosa and Acinetobacter baumannii were the most common isolates. A total of 2 345 bacterial isolates were collected from adults,which included 1 577（67.2%） of strains Gram-negative bacteria and 768 strain of （32.8%） Gram-positive bacteria; Escherichia coli,Acinetobacter baumannii, Klebsiella pneumoniae,Staphylococcus aureus,Enterococcus and Pseudomonas aeruginosa were the most common isolates. The incidences of methicillin-resistant S. aureus （MRSA） in children and adults were 19.8% and 17.8%; Escherichia coli and Klebsiella pneumoniae among children resistant to amikacin and quinolones were much lower than the adult; Pseudomonas aeruginosa and Acinetobacter baumannii among children resistant to antimicrobial drugs were lower than the adult, especially aminoglycosides and fluoroquinolones. CONCLUSION： There are some differences between children and adults in distribution of common pathogen and characteristics of drug resistance, and bacterial resistance should be continuously monitored.
出处
《中国药房》
CAS
CSCD
2012年第46期4363-4366,共4页
China Pharmacy
关键词
儿童
成人
细菌耐药性
监测
Children
Adults
Bacterial resistance
Monitor
