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暴发性肝衰竭发病机制及治疗的研究进展 被引量:4

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摘要 暴发性肝衰竭(fulminant hepatic failure,FHF)是指患者急骤起病,突然出现大量肝细胞坏死或肝功能显著异常,并在首发症状出现后8周内发生肝性脑病(hepaticenc ephalopathy,HE)等表现的一种综合征。其临床特点是起病急、病情危重、症状表现多样,病死率高达80%-90%。在美国,FHF的自然生存率为45%,25%的患者可以接受肝移植治疗,其中35%肝移植术后可获得良好生存。然而目前有效的治疗手段非常有限,因而FHF在临床上引起特别关注。
作者 裘云庆 喻玮
出处 《浙江中西医结合杂志》 2012年第11期920-922,F0003,共4页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
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  • 1何文寿,高敏.肝性脑病的发病机理与诊断[J].中国冶金工业医学杂志,2005,22(2):124-126. 被引量:3
  • 2杨林 ,DENG Yi-bin ,WU Xiang-wei .Bcl-xl阻断肿瘤坏死因子α诱导的caspase 8活化及细胞凋亡[J].中华肝脏病杂志,2005,13(4):286-289. 被引量:4
  • 3朱清静,陈锋,盛国光.大黄对暴发性肝衰竭大鼠肝损伤及肝再生的影响[J].中国中西医结合消化杂志,2006,14(1):5-7. 被引量:30
  • 4曹健美,王晓柠,彭景华,胡义扬.内毒素诱导的库普弗细胞活化对肝细胞损伤的影响及姜黄素的干预作用[J].上海中医药杂志,2006,40(4):56-58. 被引量:3
  • 5Jonsson-Berling BM, Ohlsson K. Distribution and elimination of intravenously injected urinary trypsin inhibitor [ J ]. Scand J Clin Lab Invest, 1991, 51(6): 549-557.
  • 6Lin SD, Endo R, Sato A, et al. Plasma and urine levels of urinary trypsin inhibitor in patients with acute and fuhninant hepatitis [ J ]. J Gastroenterol Hepatot, 2002, 17 (2) : 140-147.
  • 7Salier JP, Rouet P, Raguenez G, et al. The inter-alpha-inhibitor family: from structure to regulation [J]. Biochem J, 1996, 315 ( Pt 1) : 1-9.
  • 8lnoue K, Takano H, Shimada A, et al. Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide [ J]. Mol Pharmacol, 2005, 67 (3) : 673-680.
  • 9Okabe H, Irita K, Kurosawa K, et al. Increase in the plasma concentration of reduced glutathione observed in rats with liver damage induced by lipopolysaccharide/D-galactosamine: effects of ulinastatin, a urinary trypsin inhibitor [ J]. Circ Shock, 1993, 41 (4) : 268-272.
  • 10Kondo Y, Takano F, Yoshida K, et al. Protection by sinomenine against endotoxin-induced fulrninant hepatitis in galaetosamine-sensitized mice [J]. Bioehem Pharmacol, 1994, 48(5): 1050-1052.

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  • 1Tao Han,Ying Liu,Huan Liu,Zheng-Yan Zhu,Yan Li,Shi-Xiang Xiao,Zhen Guo,Zhen-Gang Zhao.Serum thymosinβ4 levels in patients with hepatitis B virus-related liver failure[J].World Journal of Gastroenterology,2010,16(5):625-630. 被引量:21
  • 2郑淑梅,刘文彬,王云侠,周颖,张宏伟.儿童慢性乙型肝炎细胞免疫功能及胸腺素疗效[J].中国临床药学杂志,2005,14(2):77-79. 被引量:2
  • 3无.肝衰竭诊疗指南[J].药品评价,2007,4(1):3-7. 被引量:12
  • 4Goldstein AL, Guha A, Zatz MM, et al. Purification and biologicalactivity of thymosin, a hormone of the thymus gland[j]. Proc NatlAcad Sci USA,1972,69(7):1800-1803.
  • 5Ciancio A, Rizzetto M. Thymalfasin in the treatment of hepatitisB and C[J]. Ann NY Acad Sci,2010,1194:141-146.
  • 6Garaci E, Pica F, Serafino A, et al. Thymosin alpha 1 and cancer:action on immune effector and tumor target cellsfJ]. Ann N YAcad Sci,2012,1269:26-33.
  • 7Bozza S, Gaziano R, Bonifazi P, et al. Thymosin alpha 1 activatesthe TLR9/MyD88/IRF7-dependent murine cytomegalovirussensing for induction of anti-viral responses in vivo[J]. IntImmunol,2007,19( 11): 1261-1270.
  • 8Serafino A, Pierimarchi P, Pica F, et al. Thymosin alpha 1 as astimulatory agent of innate cell-mediated immune response[J].Ann NY Acad Sci,2012,1270:13-20.
  • 9Hadden JW. Immunodeficiency and cancer: prospects forcorrection[J]. Int Immunopharmacol,2003,3(8): 1061 -1071.
  • 10WuJ, Zhou L, Liu J, et al. The efficacy of thymosin alpha 1 forsevere sepsis (ETASS): a multicenter, single-blind, randomizedand controlled trial [J]. Crit Care,2013,17(1):R8.

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