摘要
目的分析细菌性乳腺炎患者病原菌分布及其耐药性现状,为临床合理使用抗菌药物提供参考依据。方法收集医院2010年1月-2011年12月细菌性乳腺炎患者的脓液标本进行细菌培养及药敏试验。结果 124例标本病原菌的分离率为47.6%,以金黄色葡萄球菌为主,占72.88%;金黄色葡萄球菌对青霉素、红霉素的耐药率分别为90.70%和76.74%,而对万古霉素、左氧氟沙星、四环素、磺胺甲噁唑/甲氧苄啶、呋喃妥因及苯唑西林等的耐药率均<20.00%;金黄色葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)检出率为20.93%,44.19%可产生β-内酰胺酶。结论细菌性乳腺炎以金黄色葡萄球菌检出率最高,对青霉素、红霉素有较高耐药性,可将苯唑西林作为治疗细菌性乳腺炎首选药物;应加强细菌培养及药敏检查,根据药敏结果合理使用抗菌药物。
OBJECTIVE To investigate the distribution and antimicrobial resistance of pathogens isolated from the patients with bacterial mastitis so as to provide reference for clinical reasonable use of antibiotics.METHODS The pus specimens were collected from the patients with bacterial mastitis from Jan 2010 to Dec 2011,the bacterial culture and the drug susceptibility testing were performed.RESULTS The isolation rate of the pathogenic bacteria from 124 specimens was 47.6%,Staphylococcus aureus（70.49%） was the main species isolated,the drug resistance rates of S.aureus to penicillin and erythromycin were 90.70% and 76.74%,the resistance rates of S.aureus were all below 20.00% to vancomycin,levofloxacin,acheomycin,sulfamethoxazole/trimethoprim,and furantoin and oxacillin;the detection rate of methicillin-resistant S.aureus（MRSA） among S.aureus strains was 20.93%,and 44.19% could produce beta-lactamase.CONCLUSION The major pathogen in S.aureus is the major species of pathogens to be detected to cause bacterial mastitis and is highly resistant to pencillin and erythmmycin,the oxacillin can be selected as the first line drug for bacterial mastitis;it is necessary to strengthen the bacterial culture and the drug susceptibility testing as well as to reasonably use antibiotics according to the drug susceptibility testing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第22期5035-5037,共3页
Chinese Journal of Nosocomiology
关键词
细菌性乳腺炎
金黄色葡萄球菌
耐药性
Bacteria mastitis
Staphylococcus aureus
Antimicrobial resistance
