摘要
目的评价丙泊酚-芬太尼复合方法下行儿童胃镜检查术的安全性和有效性。方法拟行胃镜检查术的患儿。150例，随机分为5组：丙泊酚组（P组），丙泊酚一氯胺酮组（PK组），丙泊酚芬太尼组（PF组），咪达唑仑-芬太尼组（MF组）、咪达唑仑-氯胺酮组（MK组），每组30例。记录各时段血压（BP）、呼吸（R）、心率（HR）、脉搏血氧饱和度（SpO2）。观察呼吸，佤环的变化，以及麻醉诱导、维持与苏醒时间，术后不良反应。结果MK、MF组诱导时间与苏醒时间较长（P〈0．05）；P组丙泊酚用量较多（P〈0．05），且术中SpO2值较低（P〈0．05）；MK组给药后心率明显增快，P组给药后心率减慢（P〈0．05）；与其他组比较，P组下镜抵抗、低氧血症及术后头晕头痛发生率高（P〈0．05）；P、MK及MF组术中体动发生率较高（P〈0．05）；PK、MK组术后不良反应较多（P〈0．05）。结论丙泊酚联合芬太尼用于儿童无痛胃镜检查术安全有效，且术中生命体征平稳，术后不良反应少。
Objective To observe the efficacy of propofol combined with fentanyl in the pain less gastroscopy for children. Methods One hundred and fifty children undergoing gastroscopy were randomly divided into 5 groups： propofol group （group P）, propofolketamine group （group PK）, propofolfentanyl group （group PF）, midazolamfentanyl group （group MF）, midazolamketamine group （group MK）, 30 cases in each group. Blood pressure （BP）, respiration（R）, heart rate （HR）, and SpO2 were recorded. Anesthesia induction, maintenance and postoperative recovery times, and the adverse reactions were also recorded. Results The induction time and recovery time were longer in group MK and MF（P〉0.05）. The dosage of propofol was more, and SpO2 was lower in group P （P〈0.05）. Heart rate was significantly increased after the administration in group MK, heart rate after the administration was decreased in group P（P〈0.05）. Compared with other groups, .the inci dence rates of resistance to entering gastroscopy, hypoxemia and postoperative dizziness and headache were high in group P（P〈0. 05）. The incidence rates of intraoperative body movement were higher in group P.MK and MF （P〈0. 05）. The incidence rates of postoperative adverse reactions were higher in group PK and MK（P〈0.05）. Conclusion Propofol combined with fentanyl is an effective and safe method for children undergoing gastroscopy with stable vital signs and less adverse reactions.
出处
《实用疼痛学杂志》
2012年第4期274-277,共4页
Pain Clinic Journal
