摘要
目的探讨颅骨嗜酸性肉芽肿的临床表现、诊断和治疗。方法对2003年1月至2010年12月间我科收治的儿童颅骨嗜酸性肉芽肿48例进行回顾性分析。所有病例术前均行头颅CT检查，其中12例行头颅MRI检查，均行长骨和扁骨的X线片检查，均行手术治疗和病理检查。结果顶骨为好发骨。1例多发，1例合并锁骨病变。所有病例均行手术全切，术后均未行放疗。15例因局部硬脑膜、帽状腱膜受浸，术后应用吲哚美辛治疗6周。随访6个月至7年（平均3．2年），均无复发。结论颅骨嗜酸性肉芽肿为良性病变，在诊断时需警惕多发病灶。手术切除是单发病灶的最佳治疗方法，术后不需要侵袭性化疗和放疗，预后好。
Objective To investigate the clinical manifestation, the diagnosis and treatment of skull eosinophilic granuloma. Methods 48 patients with skull eosinophilic granuloma admitted into Childrer＇s Hospital of Chongqing Medical University from July 2003 to December 2009 were analyzed retrospectively. They were all preoperatively evaluated by skull x-ray and computed tomography, with 12 patients additionally underwent magnetic resonance imaging. To rule out multifocal disease, long bone and flat bone X-rays were performed in all cases preoperatively. Surgical excision of the lesions was performed, and EG was proven histologically. Results Parietal bone was the most commonly af-fected bone. One patient had multifocal disease. One patient combined lesions of the clavicle. Total excision of the lesion was performed in all cases. No patient received postoperative radiotherapy. 15 cases had involvement of the dura and the galea aponeurotica. These patients were further treated with indomethacin for 6 weeks. Follow-up examinations ranged from 6 months to 7 years, with a mean fol-low-up period of 3. 2 years. No tumor recurrence was noted. Conclusions Skull eosinophilic granulo-ma is a benign disease. At the time of diagnosis, a bone scan should be performed to rule out multifo-cal disease. Surgical resection is the treatment of choice. No aggressive chemotherapy and radiothera-py after surgery is needed. The overall prognosis for EG of the skull is good.
出处
《中华小儿外科杂志》
CSCD
北大核心
2012年第11期805-808,共4页
Chinese Journal of Pediatric Surgery
