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分子检测在遗传性非息肉病性大肠癌筛查中的应用 被引量:1

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摘要 遗传性非息肉病性大肠癌(hereditary non—polyposis colorectal cancer,HNPCC)是遗传性大肠癌中最常见的类型,占新发大肠癌的2%~5%。HNPCC家族中男性罹患率为68.7%,女性为52.2%,因此,早期识别潜在HNPCC患者并加强肿瘤监视,通过定期结肠镜检查,继而降低HNPCC死亡率是非常重要的。HNPCC除具备散发性大肠癌的一般临床特征外,还具有发病年龄较轻、发病部位多位于右半结肠以及伴有大肠外器官肿瘤等临床特点。
出处 《中华消化内镜杂志》 2012年第11期656-658,共3页 Chinese Journal of Digestive Endoscopy
基金 基金资助:卫生部临床重点学科项目(2010~2012) 2009年上海市科委生物医药处面上项目(09411967100) 2011年国家自然科学基金(81101566)
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