摘要
目的 研究血栓调节蛋白 (TM)在胃癌组织中的表达。方法 应用免疫组织化学ABC法对 40例手术切除胃癌标本进行TM表达的研究。结果 18例肠型胃癌中 ,15例TM表达阳性(83.3% ) ,2 2例弥漫型胃癌中 ,11例TM表达阳性 (5 0 .0 % ) ;6 0岁以上病人 2 3例 ,其中 19例TM表达阳性 (82 .6 % ) ,6 0岁以下病人 17例 ,其中 7例TM表达阳性 (41.2 % )。肠型胃癌TM的表达明显高于弥漫型胃癌 (P <0 .0 5 ) ;6 0岁以上病人胃癌组织TM的表达显著高于 6 0岁以下的病人 (P <0 .0 5 )。结论 肠型胃癌TM的表达显著高于弥漫型胃癌。
Objective\ To study the expression of thrombomodulin (TM) in gastric carcinoma.Methods\ The expression of TM in 40 cases of gastric carcinoma was detected by means of immunohistochemical ABC.Results\ Among the 18 cases of gastric carcinoma of intestinal type, 15 were positive for TM (83.3%), 11 out of 22 cases of gastric carcinoma of diffuse type were positive for TM(50.0%), 19 of 23 gastric carcinoma patients over 60 years old were positive for TM (82.6%), 7 of 17 gastric carcinoma patients under 60 years old were positive for TM (41.2%), showing that the expression of TM in gastric carcinoma of intestinal type was significantly higher than that in gastric carcinoma of diffuse type, and that the expression of TM in gastric carcinoma patients over 60 years old was significantly higher than in those under 60 years old.Conclusion\ TM was overexpressed in gastric carcinoma of intestinal type as compared with that in gastric carcinoma of diffuse type.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2000年第2期143-144,共2页
Chinese Journal of Experimental Surgery
关键词
血栓调节蛋白
基因表达
胃肿瘤
Thrombomodulin
\ Gastric carcinoma
\ Gene expression
