摘要
目的 了解促排卵药物对多囊卵巢综合征 (PCOS)患者黄体中期子宫内膜整合素αv、β3表达的影响。方法 应用单克隆抗体 ,采用免疫组织化学技术对 2 2例正常妇女、40例无排卵PCOS患者促排卵治疗后黄体中期的子宫内膜整合素αv、β3 进行测定。结果 正常妇女子宫内膜整合素αv、β3 表达在“着床窗口期”呈现强阳性 ;而氯米芬 (CC)及绝经期促性腺激素 (hMG)抑制αv、β3 的表达 ,使其表达呈弱阳性 ;而促性腺激素释放激素激动剂对整合素αv、β3 的表达无影响。结论 CC、CC/hMG促排卵周期的黄体中期子宫内膜容受性下降 ,整合素αv、β3 表达下降或缺失。
Objective To study the endometrial integrins α v?β 3 expressions during mid luteal(ML) phase in polycystic ovarian syndrome (PCOS) related infertile patients receiving ovulation induction therapies. Methods Immunohistochemical methods using monoclonal antibody against integrins α v?β 3 were performed on endometrium of ML phase obtained from 22 normal subjects and 40 PCOS related anovulatory patients who underwent ovulation induction therapy by one of the following regimens: clomiphene citrate (CC) +human chorionicgonadotropin (hCG),CC+human menopausal gonadotropin (hMG)+hCG,or gonadotropin releasing hormone agonist +hMG+hCG. Results The expressions of endometrial integrin α v?β 3 during ML phase in GnRHa +hMG+hCG cycles were similar with those in normal natural cycles, but were weaker in CC+hCG,CC+hMG +hCG cycles as compared with controls. Conclusion CC+hCG, CC+hMG+hCG regimens may induce decline of endometrial receptivity in ML phase.
出处
《中华妇产科杂志》
CSCD
北大核心
2000年第3期163-165,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
子宫内膜
受体
透明连接素
卵植入
排卵诱导
多囊卵巢综合征
Endometrium
Receptors
vitronectin
Ovum implantation
Ovulation induction
Polycystic ovary syndrome
