摘要
目的 探讨妊娠高血压综合征 (妊高征 )患者血浆C 型利钠肽水平的变化 ,及其与妊高征发病的关系。方法 采用放射免疫分析法测定了 89例妊高征患者 (妊高征组 )、193例正常妊娠妇女 (正常妊娠组 )和 46例正常孕龄妇女 (正常妇女组 )血浆C 型利钠肽水平。结果 妊高征组血浆C 型利钠肽水平明显升高 ,为 (30 .5 1± 33.6 1)ng/L ;正常妊娠组为 (19.43± 5 .13)ng/L ,正常妇女组为(17.15± 3.82 )ng/L。妊高征患者血浆C 型利钠肽水平明显高于正常妊娠妇女。妊高征组轻、中、重患者之间 ,血浆C 型利钠肽水平亦有极显著差别 ,分别为 (9.88± 2 .74)ng/L、(2 2 .15± 8.90 )ng/L和(6 4.2 6± 44 .0 3)ng/L ,3者比较 ,差异有极显著性 (P <0 .0 1)。结论 血浆C 型利钠肽水平由低到高的变化反映妊高征的疾病严重程度 ,可作为判断妊高征病情发展的一个生化指标。
Objective To investigate the changes and clinical significance of plasma type C natriuretic peptide (CNP) concentration in patients with pregnancy induced hypertension (PIH). Methods Plasma CNP levels were detected by radioimmunoassay in 89 patients with PIH, 193 normal pregnant women and 46 normal non pregnant women. Outcomes were statistically analyzed by one way analysis of variance and Student Nawman Kenls (SNK) test. Results The plasma CNP levels in patients with PIH [(30.51±33.61) ng/L] were significantly higher than those of normal non pregnant women and normal pregnancies [(17.15±3.82) ng/L, (19.43±5.13) ng/L, respectively; F=13.61, P <0.01]. There was significant difference among plasma CNP levels from patients with mild, moderate, and severe PIH ( P <0.000 1). Conclusions The changes of plasma CNP levels are believed to be the reflection of patients in progression of PIH and can be used as a biochemical marker for judging the progression and guiding the therapy of PIH.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2000年第3期139-141,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
心钠素
妊娠并发症
心血管
高血压
放射免疫测定
Atrial natriuretic factor
Pregnancy complications,cardiovascular
Hypertension
Radioimmunoassay
