摘要
目的研究老年性吸烟稳定期COPD应用噻托溴铵的临床疗效。方法分析2009年1月～2011年9月我院收治的90例老年性吸烟稳定期COPD患者,随机分成治疗组和对照组个45例:治疗组(每日给予患者18μg噻托溴铵吸入剂+沙丁胺醇气雾剂);对照组(每隔12小时给予患者口服0.1 g氨茶碱+沙丁胺醇气雾剂),治疗后对患者进行2个月的随访观察,比较两组患者治疗后肺功能的改善情况。结果治疗组经过治疗后St George评分显著降低,优于对照组,并且相对于治疗前FEV1/Pred、FEV1、FEV1/FVC的评分值均有显著提高(P<0.01),对照组治疗效果不明显(P>0.05)。结论噻托溴铵吸入剂联合沙丁胺醇气雾剂可以显著改善老年性吸烟稳定期COPD患者的肺功能。
Objective To investigate the clinical efficacy of tiotropium inhaler in elderly smokers with stable chronic obstructive pulmonary disease （COPD）. Methods 90 elderly smokers with stable COPD were evenly and randomly divided into two groups, and their clinical data were reviewed. The treatment group were given inhaled tiotropium 18 micrograms and albuterol aerosol once a day, and the control group were treated with O. 1 g aminophylline and albuterol aerosol orally every 12 hours. All the patients were followed up for 2 months to observe their improvement. Results In the treatment group, their St George score decreased significantly compared with the control group, and the scores of FEV1/Pred, FEV1, and FEVL/FVC increased obviously （P 〈 0.01 ）. However, the control group showed no significant difference （ P 〉 O. 05 ）. Conclusion Inhaled tiotropium and salbutamol aerosol can significantly improvc lung func- tion and life quality of elderly smokers with stable COPD.
出处
《临床肺科杂志》
2012年第12期2198-2199,共2页
Journal of Clinical Pulmonary Medicine
