摘要
目的 :探讨幽门螺杆菌 ( Hp)细胞毒素相关基因 A阳性株 ( cag A+ 株 )与胃癌的关系。方法 :通过多聚酶链反应 ( PCR)检测 92例胃癌和 2 4例浅表胃炎组织石腊标本 Hp和 cag A+亚型株的感染。结果 :1Hp感染在胃癌和慢性浅表胃炎间无差异 ,而 cag A+株感染是前者高于后者 ( P<0 .0 5 ) ;2 Hp感染早期胃癌高于进展期癌、胃窦癌高于贲门癌、肠型胃癌高于弥漫型癌 ( P<0 .0 5 )。然而只有肠型胃癌 cag A+ 株感染显著高于弥漫型癌 ( P=0 .0 0 13 5 )。结论 :胃癌不同组织类型感染 Hp亚型的程度不同 ,Hp- cag A+ 株感染率在肠型胃癌中显著增高。从而推测产生细胞毒素的 Hp菌株 。
Objective:To study the relationship between Helicobacter pylori, particularly the cytotoxin associated gene (cagA) positive strains, and gastric carcinogenesis. Methods:PCR assay for the detection of Hp and cagA positive strains were used in gastric cancer (GC, n /92) and chronical superficical gastritis (CSG, n =24) with specific primers of ureA and cagA gene. Results:① there were no significant difference between the tissues of GC and CSG about Hp infection, however, infection of cagA positive strains was higher in the tissues of GC than CSG. ②Hp infection were associated with early GC, antral GC and intestinal type GC, however, cagA positive strains had a crucial relationship to the intestinal type GC only ( P =0 0135). Conclusion:different Hp strains play a differenet role in gastric carcinogensesis. Infection with Hp strains possessing cagA gene had a close relationship with the GC, particularly the intestinal type GC, so cagA positive strains might contribute to pathogenesis of gactric cancinoma.
出处
《军医进修学院学报》
CAS
2000年第1期59-61,共3页
Academic Journal of Pla Postgraduate Medical School
