摘要
对采用 Norplant R埋植剂和仿制 Norplant的国产埋植剂 型避孕的育龄妇女骨密度和骨代谢改变进行了 1年的随机前瞻性临床观察。 6 1例正常妇女被分为两组 :Norplant埋植剂组 30例 ,国产埋植剂组 31例。两组于埋植前和埋植后第 12个月时采用双能 X线骨密度测定仪 (DEXA)分别测定了腰椎 L2 ～ L4、股骨近端骨密度和骨矿含量。两组妇女埋植后第 12个月时腰椎 L2 ～ L4骨密度和骨矿含量均较埋植前明显增加 (P<0 .0 1) ,Norplant组骨密度平均增加2 .40 % ,骨矿含量平均增加 3.34 % ,国产埋植剂组分别增加 2 .75 %和 4.47% ;从年龄分析 ,以 2 5～ 2 9岁组腰椎 L2 ～ L4骨密度埋植后增加最为显著 ,Norplant组 P<0 .0 5 ,国产埋植剂组 P<0 .0 1。国产埋植剂组妇女埋植后第 12个月时股骨大粗隆骨密度和骨矿含量较埋植前明显增加 (P<0 .0 1) ;国产埋植剂组妇女空腹尿羟脯氨酸 /肌酐比值埋植后第 12个月时较埋植前明显下降 (P<0 .0 1) ;对使用妇女腰椎、股骨骨密度和骨代谢生化指标的影响 ,在两种埋植剂之间埋植前后比较均无显著差别 (P>0 .0 5 )。左旋 - 18甲基炔诺酮皮埋避孕剂对绝经妇女的骨骼是非有害的 ,对年轻妇女骨峰值的获得无明显影响。
A prospective randomized clinical trial was undertaken to compare the effects of Norplant R long term contraceptive implants and domestic implants similar to Norplant on bone mineral density and bone metabolism in female acceptors for one year.Bone mineral density(BMD) and bone mineral content(BMC) of lumbar2～4 and proximal femur of sixty one normal child bearing age women were measured by dual energy x ray absorptiometry (DEXA) before and 12 months after implants insertion in both groups.BMD and BMC of lumbar 2～4 in both groups 12 months after implants insertion significantly increased ( P <0.01);with average increase of 2.40% and 3.34% respectively in the Norplant implants group,and 2.75% and 4.47% respectively in the domestic implants group.The hydroxyproline and creatinine ratio (Hop/Cr) in the domestic implants group decreased significantly( P <0.01).There were no significant differences in the effects on BMD and BMC of lumbar spine and femur and on bone metabolism between two groups of contraceptive implants( P >0.05).Levonorgestrel subdermal contraceptive implants was not deleterious to the skeleton in premenopausal women and there was no siginificant effect on achieving maximum bone mass in young women.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2000年第3期156-159,共4页
Journal of Practical Obstetrics and Gynecology
关键词
甲基炔诺酮
骨密度
骨代谢
皮下埋植避孕剂
Levonorgestrel
Contraception
Bone mineral density
Bone metabolism
Norplant R premenopausal women
