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血管内皮生长因子与卵巢癌 被引量：1

Vascular Endothelial Growth Factor and Ovarian Carcinoma
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摘要 血管内皮生长因子 (VEGF)能强烈促进血管内皮细胞有丝分裂、血管生成 ,增加血管通透性。VEGF及其受体在许多肿瘤包括卵巢肿瘤中表达 ,并在卵巢癌高表达 ,与卵巢癌的发生、发展、转移和预后等密切相关。通过检测、抑制VEGF,可能为卵巢癌的早期诊断、治疗开辟新的途径。 Vascular Endothelial Growth Factor is a highly specific mitogen for vascular endothelial cells.It potentiates angiogenesis and promotes the vascular permeability.Strong expression of VEGF and its receptor has been found in various solid tumor types,including ovarian carcinoma.Measurement and neutralization of VEGF activity may have clinical application in early diagnosis and therapy of ovarian carcinoma.
作者 罗军 综述 王和 彭芝兰
机构地区 四川省人民医院 华西医科大学附属第二医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2000年第3期131-133,共3页 Journal of Practical Obstetrics and Gynecology
关键词 血管内皮生长因子 卵巢癌 肿病发生 肿瘤转移 Vascular Endothelial Growth Factor Ovarian carcinoma Expression
分类号 R737.31 [医药卫生—肿瘤]
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参考文献17

  • 1Sowter HM, et al. Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors. LabInvest, 1997,77 (6): 607～14.
  • 2Wiesmann C,et al. Crystal structure at 1.7 angstrom resolution of VEGF in complex with domain 2 of the Fit-1 receptor. Ce11,1997,91:695～704.
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实用妇产科杂志
2000年 第3期

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