摘要
目的:探讨参附强心丸对慢性心力衰竭(CHF)心功能及对脑钠素及炎性因子水平的影响。方法:76例CHF患者随机分为治疗组39和对照组37例。对照组采用西医常规治疗,治疗组在西医常规治疗的基础上加用参附强心丸6 g 1次,2～3次/d。疗程8周。观察两组心功能、左心功能、中医证候积分、N末端B型尿钠肽(NT-proBNP)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)及白介素-6(IL-6)水平的变化。结果:治疗组降低左室舒张末期内径(LVEDD)及增加心室射血分数(LVEF)方面优于对照组(P<0.01);治疗组中医证候积分低于对照组(P<0.01);治疗组血浆NT-proBNP水平低于对照组(P<0.01);治疗组血浆CRP,TNF-α及IL-6水平均低于对照组(P<0.01)。结论:参附强心丸能显著改善CHF患者心脏舒缩功能,降低中医证候积分,降低其血浆NT-proBNP水平,其作机制可能与抑制炎性细胞因子减轻炎症反应有关。
Objective： To investigate the impact of Shenfu Qiangxin pills on cardiac function, brain natriuretic peptide and inflammatory factor levels on patients with chronic heart failure （CHF）. Method： Seventy- six cases of CHF were equally divided into treatment group （39 cases） and control group （37 cases）. The control group was given conventional western treatment, the treatment group was used Shenfu Qiangxin pills 6 g, tid for 8 weeks on the basis of the control group. Cardiac function, left Ventricular function, traditional Chinese medicine （TCM） syndrome score, N-terminus of the original brain natriuretic peptide （NT-proBNP） , C-reactive protein （CRP）, tumor necrosis factor （TNF-~） and interleukin-6 （IL-6） in the two groups were observed before and after the intervention. Result： The treatment group was better than the control group on the aspects of decreasing left ventricular end diastolic diameter （LVEDD） and increasing ventricular ejection fraction （LVEF） （P 〈 0. 01 ）. The TCM syndrome scores, plasma NT-proBNP level, plasma CRP, TNF-a and IL-6 levels in the treatment group were lower than those in the control group （ P 〈 0.01 ）. Conclusion： Shenfu Qiangxin pills can significantly improve cardiac function in patients with CHF, reduce TCM syndrome score and reduce the level of plasma NT- proBNP. Its mechanism may be related to the inhibition of inflammatory cytokines to reduce the inflammatory response.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第22期319-321,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
参附强心丸
慢性心力衰竭
心功能
N-末端原脑利钠肽
炎性因子
Shenfu Qiangxin pills
chronic heart failure
cardiac function
N-terminus of the original brain natriuretic peptide
inflammatory factors
