摘要
本文系统地介绍了QTL定位的单一标记分析法、区间作图法以及复合区间作图法、混合显性模型的分析方法 ,概述了一些主要定位方法的分析原理、存在的主要优缺点。单一标记分析法可以采用方差分析、回归分析或似然比检验的方法分析。区间作图法和复合区间作图法是基于两个相邻标记的QTL定位方法 ,可采用回归分析或最大似然法分析。复合区间作图法在模型中包括了与其他QTL连锁的标记 ,可以提高作图的精度和效率。混合线性模型的QTL定位方法可以包括复杂的遗传效应及QTL与环境的互作效应 ,具有更广阔的应用前景。
QTL mapping methods are reviewed for single marker mapping, interval mapping, composite interval mapping, and mixed model based method. Statistical approaches along with their properties are discussed for the mapping methods.ANOVA, regression method and likelihood ratio test can be applied in single marker mapping. Interval mapping and composite interval mapping can be conducted, based on two interval markers, by regression method and maximum likelihood method. Since markers linked with other QTLs are include in the model, composite interval mapping is more precision and powerful. Mapping QTL by mixed model approaches is more applicable when complicated QTL effects as well as QTL by environment interaction are analyzed.
出处
《遗传》
CAS
CSCD
北大核心
2000年第3期175-179,共5页
Hereditas（Beijing)
基金
国家自然科学基金重大项目!(编号 :39893350)资助
