摘要
目的:系统评价高剂量左氧氟沙星与常规剂量治疗呼吸道感染的疗效与安全性。方法:检索中国知网全文数据库(CNKI)、万方数据库、维普中文科技期刊数据库、Medline、Sciencedirect上的文献,并对数据采用Rev Man 5.0进行Meta分析。结果:共纳入了5项研究(包含1655例患者)。Meta分析结果显示,高剂量与常规剂量左氧氟沙星治疗呼吸道感染的有效率无显著性差异[OR=1.38,95%CI(0.92,2.06),P=0.12],细菌清除率无显著性差异[OR=1.74,95%CI(0.98,3.10),P=0.06],不良反应发生率也无显著性差异[OR=1.21,95%C(I0.70,2.11),P=0.49]。进行敏感分析后得到的结论类似。结论:高剂量左氧氟沙星在治疗呼吸道感染的有效率、细菌清除率、不良反应发生率方面与常规剂量比较无显著性差异,但是提高剂量可以减少耐药发生、增加患者依从性并降低治疗成本。
OBJECTIVE：To evaluate the clinical efficacy and safety of high-dose and routine-dose of levofloxacin in the treatment of respiratory tract infection.METHODS：We searched CNKI,Wanfang Database,VIP,Medline and Sciencedirect.Meta-analysis was performed using Rev Man 5.0 software.RESULTS：5 trials were involved,including 1 655 cases.Results of Meta-analysis,there was no significant difference in the effectiveness of high-dose and routine-dose of levofloxacin in the treatment of respiratory tract infection [OR=1.38,95%CI（0.92,2.06）,P=0.12].There was no significant difference in bacteriologic eradication rates [OR=1.74,95%CI（0.98,3.10）,P=0.06].There was no significant difference in the incidence of adverse drug reactions [OR=1.21,95%CI（0.70,2.11）,P=0.49].The results of sensitivity analysis were also consistent with the above findings.CONCLUSION：There is no significant difference in the effectiveness,bacteriologic eradication rates and the incidence of adverse drug reactions between high-dose of levofloxacin and routine-dose levofloxacin.The increase of drug dose can diminish the incidence of drug resistance,improve compliance and lower cost.
出处
《中国药房》
CAS
CSCD
2012年第44期4204-4207,共4页
China Pharmacy
