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心肌梗塞与细胞凋亡关系的初步探索 被引量:3

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摘要 探索人类心肌梗塞时心肌细胞凋亡的证据。选用TUNEL的方法对 2 2例急慢性心肌梗塞的心肌标本及 14例无心血管疾病的心肌标本进行检测。应用免疫组化的方法对细胞凋亡的相关基因Bcl 2和Bax进行检测。急性梗塞区及梗塞周边区凋亡细胞明显增多 ,以周边区域最为明显 (P <0 .0 0 1) ;陈旧梗塞区仍能见到凋亡细胞 ,较急性区域明显减少 (P <0 .0 0 1) ;在梗塞组正常区域及对照组偶见有凋亡细胞 ,2组间无显著差异。在人类心肌梗塞的细胞学检测中发现有大量的凋亡细胞 。
作者 刘琦 常志文
出处 《心肺血管病杂志》 CAS 2000年第2期110-113,共4页 Journal of Cardiovascular and Pulmonary Diseases
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参考文献9

  • 11,Kerr,JFR,WyllieAH,CurrieAR.Apoptosis:abasicbiologicalphenomenonwithwiderangingimplicationsintissuekinetics.BrJCancer,1972,26:239~257.
  • 22,RichardoHB,HaileyLS,XieSS,etal.Insituapoptosisassayforthedetectionofearlyacutemyocardialinfarction.AmericanJofPathol,1996,149:821~829.
  • 33,NarulaJ,HaiderN,VirmaniR,etal.Apoptosisincardiomcytesinend-stageheartfailure.NEnglJMed,1996,335:1181~1189.
  • 44,MallatZ,TedguiA,FontaliranF,etal.Evidenceofapoptosisinarrhythmogenicrightventriculardysplasia.TheNewEnglandJournalofMedicine,1996,335(16):1190~1201.
  • 55,SarasteA,PulkkiK,KallagokiM,etal.Apoptosisinhumanacutemyocardialinfarction.Circulation,1997,95:320~323.
  • 66,AnversaP,OliveitiG,MeggsLG,etal.Cardiacanatomyandventricularloadingaftermyocardialinfaract.Circulation,1993,87:22~27.
  • 77,GottliebEA,BurlesonKA,KlonerRA,etal.Reperfusioninjuryinducesapoptosisinmyocardiumofcardiomyocytes.JClinInvest,1994,94:1621~1929.
  • 88,ClearyMY,SklarJ.Nrcleotidesequenceoft(14∶18)chromosalbreakpointinfollicularlymphomaanddemostrationofbreakpoint-clusterregionnearatranscriptionallyactivelocusonchromosome18.ProcNatlAcadSciUSA,1985,82:7439~7443.
  • 99,OlitvaiZN,MillimanCL,KorsmeyerSJ.Bcl-2hetermodimerizesinvivowithaconservedhomolog,Bax,thataccelerateprogrammedcelldeath.Cell,1993,74:609~619. 修回日期:1999-10-17

同被引文献19

  • 1孙忠国,张凡,成日青,张九鸿.Fn、HSP70在冠心病猝死心肌中表达的诊断意义[J].河北北方学院学报(医学版),2007,24(1):67-70. 被引量:6
  • 2赵明中 高承梅 等.通心络胶囊对缺血再灌注心肌细胞凋亡及相关基因蛋白表达的影响[J].中华心血管病杂志,2000,28(3):206-206.
  • 3Kajstura J,Cheng W,Reiss K,et al. Apoptotic and necrotic myocyte cell, deaths are independent contributing variables of infarct size in rats. Lab lnvest, 1996,74: 86.
  • 4Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res, 1996,79:949.
  • 5James TN. Normal and abnormal consequences of apoptosis in the humsan heart. From postnatal morphogenesis to paroxysmal arrhythmias. Circulation, 1994,90: 556.
  • 6Fiss H, Gattinger D. Apoptosis in ischemic and reperfuscd rat myocardium[J]. Circ Res,1996,79:949.
  • 7,lame T N. Normal and abnormal consequences of apoptosis in the human heart Fnam postnatal moq bogenesis to paroxysmal arrhythmias[J]. Circulation, 1994,90 : 556.
  • 8赵明中,高承梅,张宇洋,等.通心络胶囊对缺血再灌注心肌细胞凋亡及相关基因蛋白表达的影响[J].中华心血管病杂志,2000,28(3):206.
  • 9Steller H.Mechanisms and genes of cellular suicide[J].Scinece, 1995, 267(52): 1445-1449.
  • 10Long X, Boluyt M O, Hipolito M L, et al.p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes[J].J Clin Invest, 1997, 99(11): 2635-2643.

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