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早期子宫颈癌患者血清骨桥蛋白的表达及其意义 被引量：5

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摘要 目的:探讨骨桥蛋白(OPN)在早期宫颈癌患者血清中的表达情况,以及与宫颈癌患者的临床病理特征的关系。方法:采集60例确诊为Ⅰa-Ⅱa期宫颈癌患者及30例健康体检者的血清样本,采用酶联免疫吸附法(ELISA)测定骨桥蛋白的含量。结果:早期宫颈癌患者血清中OPN呈现高表达,明显高于健康体检者,差异有统计学意义(P<0.01);OPN在早期宫颈癌患者血清中的表达与肿瘤的分化程度、淋巴结转移有关,差异有统计学意义(P<0.05),而与肿瘤的病理类型及临床分期无关,差异无统计学意义(P﹥0.05)。随着肿瘤的分化程度越低、淋巴结转移,OPN的血清含量越高。结论:OPN在宫颈癌的发生、发展和淋巴结转移中发挥了作用,OPN的表达水平有望作为估计宫颈癌预后的指标。
作者 张红平 刘莹 杨琳琳
机构地区 昆明医科大学第三附属医院妇瘤科
出处 《中国妇幼保健》 CAS 北大核心 2012年第32期5205-5207,共3页 Maternal and Child Health Care of China
关键词 骨桥蛋白 宫颈癌 临床病理特征
分类号 R737.33 [医药卫生—肿瘤]
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参考文献8

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共引文献7

同被引文献53

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引证文献5

二级引证文献26

中国妇幼保健
2012年 第32期

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