摘要
目的:评价伊来西胺预防小儿复杂性热惊厥(CFC)复发的效果。方法:将45例CFC患儿随机分为两组,对照组20例给予常规退热及原发病治疗;治疗组25例在发热期间每日口服伊来西胺3～5 mg/kg用至体温正常,常规辅以退热及原发病治疗。所有病例随访1年。结果:服药5 h以内,对照组和治疗组意识恢复的总有效率分别为63.27%和80.64%(P<0.05);服药48 h以内,对照组和治疗组体温恢复的总有效率分别为61.58%和79.83%(P<0.05);对照组和治疗组的CFC复发率分别为45.00%和12.00%(P<0.05);对照组和治疗组的癫痫发生率分别为15.00%和4.00%(P<0.05),并且治疗组比对照组患儿的脑电图有明显改善。结论:伊来西胺对治疗和预防CFC复发有较好的效果。
Objective： To assess the effect of Ilepcimide in curing and preventing the recurrence of complex febrile convulsion （CFC） in children. Methods： A total of 45 children with CFC were divided into control group （20 cases） and therapeutic group （25 cases） randomly. The cases of the control group were treated the routine therapy of pyretolysis and the primary diseases. The cases of the thera- peutic group took Ilepcimide 3 - 5 mg/kg/d orally during the febre durante until the body temperature recovered. The methods of pyretolysis and the therapy of the primary diseases were conducted routinely as well. All of the cases were followed up for 1 year. Results ： The total effective rates of conscious recovery of the control and therapeutic groups was 63.27% and 80. 64% （P 〈0. 05） respectively within 5h after taking Ilepcimide. The total effective rates of body thermometric recovery of the control and therapeutic groups was 61.58% and 79. 83% （P 〈 0. 05） respectively. The recurrent rates of CFC of the control and therapeutic groups was 45.0% and 12, 0% （P 〈 0. 05 ） respectively. The epileptic incidence rate of the control and therapeutic groups was 15% and 4% （P 〈 O. 05 ） respectively. And the electroencephalography of the therapeutic group was improved compared with that of the control group. Conclusion ： The curative and preventive effect of Ilepcimide to the recurrence of complex febrile convulsion in children is evident.
出处
《中国妇幼保健》
CAS
北大核心
2012年第32期5103-5105,共3页
Maternal and Child Health Care of China
基金
吉林省教育厅资金资助项目〔2009609〕
关键词
伊来西胺
复杂性热惊厥
治疗
预防
Ilepcimide
Complex febrile convulsion （CFC）
Therapy
Prevention
